C2CD4D Gene

HGNC Family	C2 domain containing
Name	C2 calcium-dependent domain containing 4D
Synonyms	FAM148D
Proteins	C2D4D_HUMAN
NCBI Gene ID	100191040
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

C2CD4D has 1,988 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 35 datasets.

Click the + buttons to view associations for C2CD4D from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

C2CD4D Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of C2CD4D gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of C2CD4D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of C2CD4D gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of C2CD4D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of C2CD4D gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of C2CD4D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of C2CD4D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of C2CD4D gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with C2CD4D gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by C2CD4D gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with C2CD4D gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with C2CD4D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at C2CD4D gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of C2CD4D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of C2CD4D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing C2CD4D from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing C2CD4D from the GeneSigDB Published Gene Signatures dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of C2CD4D gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of C2CD4D gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of C2CD4D gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of C2CD4D gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of C2CD4D gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for C2CD4D protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of C2CD4D gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of C2CD4D gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	cell lines with C2CD4D gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of C2CD4D gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	MoTrPAC Rat Endurance Exercise Training	tissue samples with high or low expression of C2CD4D gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
	PFOCR Pathway Figure Associations 2023	pathways involving C2CD4D protein from the PFOCR Pathway Figure Associations 2023 dataset.
	PFOCR Pathway Figure Associations 2024	pathways involving C2CD4D protein from the Wikipathways PFOCR 2024 dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of C2CD4D gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at C2CD4D gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of C2CD4D gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of C2CD4D gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with C2CD4D protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.