{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long noncoding RNA C5orf17 as a potential biomarker across diverse pathological conditions. In patients with rheumatoid arthritis, for example, C5orf17 expression was significantly dysregulated in peripheral blood mononuclear cells alongside other lncRNAs related to apoptosis and autophagy, with its altered levels correlating with clinical indexes and patient self‐perception."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another context, analysis of transcriptomes in peripheral leukocytes from patients undergoing oxaliplatin‐based chemotherapy revealed that C5orf17 was notably upregulated in individuals experiencing chemotherapy‐induced peripheral neuropathy, suggesting a role for this lncRNA in the onset of adverse treatment effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, studies in lung squamous cell carcinoma identified C5orf17 as one of several prognostically relevant lncRNAs, with its inclusion in a competitive endogenous RNA network contributing to a prognostic model that may aid in individualized patient management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings underscore the emerging relevance of C5orf17 in disease diagnosis, monitoring, and prognostication.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianting Wen, Jian Liu, Hui Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12913"}], "href": "https://doi.org/10.1002/2211-5463.12913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32569434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32569434"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manuel Morales, Julio Ávila, Rebeca González-Fernández, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pers Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/jpm4020282"}], "href": "https://doi.org/10.3390/jpm4020282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25563226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25563226"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lingyu Qi, Tingting Zhang, Yan Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of lncRNAs associated with lung squamous cell carcinoma prognosis in the competitive endogenous RNA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7727"}], "href": "https://doi.org/10.7717/peerj.7727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31576252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31576252"}]}]}]}