{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n C8orf17, originally designated MOST‐1, is a novel, intronless gene encoding a small hydrophilic protein of 99 amino acids that appears to play a role in the regulation of cellular differentiation, proliferation, and survival. Initial studies in T lymphoblastic leukemia and various cancer cell lines revealed that C8orf17 is ubiquitously expressed in malignant cells but shows differential expression in normal tissues"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Functional experiments demonstrated that C8orf17 exhibits a predominantly cytoplasmic localization with polar distribution during cell division, and its knockdown results in reduced cell proliferation accompanied by enhanced apoptosis, implying a mitogenic and pro-survival function. In addition, protein–protein interaction studies have identified associations with several molecules that are overexpressed in tumors or involved in metabolic pathways, further supporting its role in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, genomic analyses have shown that the chromosomal region 8q24.2, where C8orf17 is mapped, is amplified in high-grade breast and prostate cancers, correlating with increased gene dosage and elevated expression levels in aggressive tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, studies in gastroesophageal junction adenocarcinoma have identified a significant decrease in C8orf17 expression, suggesting that the contribution of C8orf17 to carcinogenesis may be context‐dependent."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J M M Tan, E P C Tock, V T K Chow "}, {"type": "b", "children": [{"type": "t", "text": "The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pathol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/mp.56.2.109"}], "href": "https://doi.org/10.1136/mp.56.2.109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12665628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12665628"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jeanne M M Tan, Vincent T K Chow "}, {"type": "b", "children": [{"type": "t", "text": "Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17143515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17143515"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M van Duin, R van Marion, K J Vissers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytogenet Genome Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000108293"}], "href": "https://doi.org/10.1159/000108293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18000363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18000363"}]}]}]}