{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of C9orf147 Function in Pheochromocytoma</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Integrative analyses of competing endogenous RNA (ceRNA) networks in pheochromocytoma (PCC) have identified long non‐coding RNA C9orf147 as an important molecular player with prognostic implications. In studies assessing differential RNA expression and DNA methylation patterns in malignant PCCs, C9orf147 was found among key lncRNAs whose altered expression correlated with patient survival, suggesting its role as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in an independent analysis focused on the ceRNA networks in PCC, C9orf147 was identified as an independent predictor of overall survival when evaluated alongside other lncRNAs and mRNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n Overall, these findings indicate that C9orf147 may participate in tumor-related regulatory networks and holds potential as both a prognostic biomarker and a therapeutic target in PCC.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiayi Zhang, Rong Cong, Qijie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of ceRNA network and DNA methylation associated with gene expression in malignant pheochromocytomas: a study based on The Cancer Genome Atlas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Androl Urol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tau.2020.01.29"}], "href": "https://doi.org/10.21037/tau.2020.01.29"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32420140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32420140"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying-Chun Liang, Yu-Peng Wu, Dong-Ning Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Building a Competing Endogenous RNA Network to Find Potential Long Non-Coding RNA Biomarkers for Pheochromocytoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000496043"}], "href": "https://doi.org/10.1159/000496043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30562748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30562748"}]}]}]}