{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CABCOCO1 (also referenced as C10orf107) is an uncharacterized gene that has emerged from several large‐scale genomic studies, where its variants and expression patterns have been repeatedly associated with cardiovascular and neoplastic phenotypes. In multiple genome‐wide association analyses of blood pressure traits conducted in diverse populations, genetic variants near or within CABCOCO1 have been linked to systolic and diastolic blood pressure as well as hypertension risk (1,2,3,4,5). Although its molecular function remains to be defined, its consistent association with blood pressure regulation suggests that CABCOCO1 may participate in pathways governing vascular tone or endothelial function. In addition, integrative expression and network analyses in osteosarcoma have identified CABCOCO1 as a key co‐expressed gene correlated with disease prognosis, implying a potential role in tumor progression (6). Moreover, the discovery of a chromosomal translocation resulting in a fusion between MECOM and CABCOCO1 in an acute myeloid leukemia patient further hints at a context‐dependent role in oncogenic processes (7). Overall, current evidence indicates that CABCOCO1 is a promising candidate gene whose genetic alterations and dysregulated expression may contribute to the pathogenesis of cardiovascular conditions and certain cancers, warranting further functional investigations.\n "}]}, {"type": "t", "text": "\n <ul>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "</li>\n </ul>"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, et al. 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