{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the noncoding RNA CACNA1C‐AS4 as a potential regulator of ion channel activity in cardiac cells. In one investigation using human induced pluripotent stem cell–derived cardiomyocytes, researchers observed that while overall gene expression changed during electrophysiological maturation, individual transcripts—including those for ion channel regulators like CACNA1C‐AS4—were not sufficient on their own to classify cells into specific cardiac subtypes (1). This suggests that CACNA1C‐AS4 may be part of a broader network of regulatory factors that fine‐tune ion channel expression during cardiac differentiation. In a complementary study focused on uncovering causal tissues in complex diseases through integrative genomic frameworks, candidate regulatory genes emerged via tissue-selective expression analyses (2). Although the investigation primarily prioritized tissues such as the lung for rheumatoid arthritis association, the framework highlights how regulatory elements such as CACNA1C‐AS4 could contribute to modulating gene networks in driver tissues, thereby linking them to disease susceptibility. Overall, these findings suggest that CACNA1C‐AS4 plays a modulatory role in governing ion channel function in both the context of cardiac electrophysiology and complex disease gene regulation.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "(2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sherri M Biendarra-Tiegs, Xing Li, Dan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological Phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2019.0030"}], "href": "https://doi.org/10.1089/scd.2019.0030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30892143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30892143"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lin Jiang, Chao Xue, Sheng Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-019-1801-5"}], "href": "https://doi.org/10.1186/s13059-019-1801-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31694669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31694669"}]}]}]}