{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CACNA1C-IT3 is a long non‐coding RNA that has emerged as a molecule of interest in diverse biological contexts. Although its function was not explicitly dissected in the study of electrophysiological maturation of human induced pluripotent stem cell‐derived cardiomyocytes—which focused on the correlation between ion channel regulators and electrophysiological phenotypes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "—its potential involvement in modulating ion channel–related pathways is suggested by its genomic association with CACNA1C, a gene encoding a key voltage‐dependent calcium channel subunit. In parallel, in the context of acute lymphoblastic leukemia the lncRNA CACNA1C-IT3 was found to be significantly upregulated as part of a competing endogenous RNA network, implicating it in the regulation of signaling cascades and gene expression programs that drive leukemogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the role of CACNA1C-IT3 in viral infections was not directly examined, emerging data from COVID-19 research underscore the critical nature of host regulatory networks—including those involving ion channels and non-coding RNAs—in modulating receptor expression and pathogen entry."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these studies point toward a multifaceted function for CACNA1C-IT3, wherein its dysregulation may influence ion channel regulation in cardiac cells and contribute to aberrant signaling in malignancies. Further investigations are warranted to elucidate its precise molecular mechanisms across these distinct physiological and pathological processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sherri M Biendarra-Tiegs, Xing Li, Dan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological Phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2019.0030"}], "href": "https://doi.org/10.1089/scd.2019.0030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30892143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30892143"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weimin Wang, Chunhui Lyu, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Signatures and Their Functions for Acute Lymphoblastic Leukemia: A Study Based on the Cancer Genome Atlas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.656042"}], "href": "https://doi.org/10.3389/fgene.2021.656042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34295352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34295352"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soudabeh Sabetian, Isabella Castiglioni, Bahia Namavar Jahromi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10061480"}], "href": "https://doi.org/10.3390/cells10061480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34204705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34204705"}]}]}]}