{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CACNA1G‐AS1 is an oncogenic long non‐coding RNA whose overexpression has been documented in several cancers and benign proliferative disorders. In non‐small cell lung cancer, its elevated expression correlates with increased cell invasion, migration, and epithelial‐mesenchymal transition through upregulation of HNRNPA2B1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, CACNA1G‐AS1 promotes tumor progression by acting as a competing endogenous RNA that sequesters miR‐2392, thus alleviating repression of the downstream target C1orf61."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colorectal cancer, it interacts with the epigenetic regulator EZH2 to suppress p53 expression, thereby enhancing both proliferative and invasive capacities of tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In ovarian cancer, CACNA1G‐AS1 is a component of a prognostic signature and functions as a malignant factor, with its knockdown restraining cancer cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in keloids—a benign hyperproliferative disorder of the skin—several independent studies have revealed that CACNA1G‐AS1 is upregulated and plays a multifaceted role. It promotes fibroblast invasion and migration, enhances type I collagen and calcium channel protein (CACNA1G) expression, and may act via a miR‐205–dependent mechanism as well as participate in a Wnt‐related regulatory network."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " Collectively, these findings indicate that through diverse mechanisms—ranging from modulating microRNA activity and epigenetic repression to influencing extracellular matrix production—CACNA1G‐AS1 contributes significantly to tumor aggressiveness and keloid pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P-F Yu, A-R Kang, L-J Jing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CACNA1G-AS1 promotes cell migration, invasion and epithelial-mesenchymal transition by HNRNPA2B1 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201802_14381"}], "href": "https://doi.org/10.26355/eurrev_201802_14381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29509247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29509247"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinghui Yang, Chunsheng Li, Hang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression through the miR-2392/C1orf61 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28477"}], "href": "https://doi.org/10.1002/jcp.28477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30908634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30908634"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L-J Wei, D-M Bai, Z-Y Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated lncRNA CACNA1G-AS1 aggravates the progression of colorectal cancer by downregulating p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_19902"}], "href": "https://doi.org/10.26355/eurrev_202001_19902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31957825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31957825"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jianfeng Zheng, Jialu Guo, Benben Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of lncRNAs involved in m6A regulation for patients with ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-02076-7"}], "href": "https://doi.org/10.1186/s12935-021-02076-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34238292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34238292"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xu Zhao, Xiang Jie, Ya-Kun Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CACNA1G-AS1 promotes proliferation and invasion and inhibits apoptosis by regulating expression of miR-205 in human keloid fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20192839"}], "href": "https://doi.org/10.1042/BSR20192839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495824"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiao-Jie Sun, Qiang Wang, Baofeng Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15880"}], "href": "https://doi.org/10.18632/oncotarget.15880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28404955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28404955"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ye Li, Xuebing Liang, Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CACNA1G-AS1 promotes calcium channel protein expression and positively affects human keloid fibroblast migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2018.8717"}], "href": "https://doi.org/10.3892/ol.2018.8717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29963160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29963160"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xuebing Liang, Lin Ma, Xiao Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA expression profiles and validation in keloid and normal skin tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3177"}], "href": "https://doi.org/10.3892/ijo.2015.3177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26397149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26397149"}]}]}]}