{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In the study summarized by"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", a comprehensive analysis integrating lncRNA, miRNA, and mRNA expression data in lung squamous cell carcinoma (LUSC) identified a competitive endogenous RNA (ceRNA) network in which CACNA2D3‐AS1 is one of the key long non‐coding RNAs. CACNA2D3‐AS1 appears to function as part of a prognostic lncRNA signature, where its differential expression is associated with the overall survival of LUSC patients. As a component of the ceRNA network, CACNA2D3‐AS1 is posited to act by interacting with specific miRNAs and, consequently, modulating the expression of target mRNAs involved in tumor regulatory pathways. These findings suggest that CACNA2D3‐AS1 may play an important role in the molecular mechanisms underlying tumor progression and could serve as a potentially valuable biomarker for predicting patient outcomes in LUSC.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Hu, Lutong Xu, Tao Shou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic analysis identifies three-lncRNA signature as a potentially prognostic biomarker for lung squamous cell carcinoma using bioinformatics strategy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Lung Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tlcr.2019.09.13"}], "href": "https://doi.org/10.21037/tlcr.2019.09.13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31737498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31737498"}]}]}]}