{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CADM2‐AS1 is an antisense transcript emerging from the CADM2 locus, which has been robustly implicated in a wide spectrum of behavioural and metabolic traits. Findings from recent large‐scale genetic association and meta‐analysis studies indicate that genetic variation within this locus is linked not only to physical activity, risk‐taking, educational attainment, alcohol and cannabis use, and obesity but also to mental health outcomes such as major depressive disorder, anxiety, bipolar disorder, neuroticism, and mood instability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise molecular role remains to be fully elucidated, CADM2‐AS1 is postulated to function in regulating CADM2 expression. This regulatory role may, in turn, influence the integrated pathways that connect the physiological systems governing both mental and physical well‐being. Further functional studies are warranted to clarify how CADM2‐AS1 contributes to the modulation of CADM2-related mechanisms and to better understand its impact on the interconnected spectrum of behavioural and metabolic traits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Morris, Mark E S Bailey, Damiano Baldassarre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in CADM2 as a link between psychological traits and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43861-9"}], "href": "https://doi.org/10.1038/s41598-019-43861-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31089183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31089183"}]}]}]}