{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although neither abstract explicitly details the function of CADM2‐AS2, the studies provide important context for understanding the broader CADM2 locus. CADM2 is robustly associated with a range of behavioural and metabolic traits—including physical activity, risk‐taking, substance use, mood instability, and obesity—as well as a shared genetic risk between psychiatric and cardiometabolic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a large, genome‐wide analysis, genetic variation in CADM2 was linked with risk‐taking behaviour—a trait that is interrelated with other psychiatric conditions such as schizophrenia, bipolar disorder, and attention‐deficit hyperactivity disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n CADM2‐AS2, as an antisense transcript at the CADM2 locus, is likely to play a regulatory role in controlling CADM2 expression, and thereby modulate these diverse cognitive, executive, metabolic, and psychiatric phenotypes. Given that antisense RNAs often fine‐tune the expression of their sense counterparts, CADM2‐AS2 may contribute to the molecular mechanisms that underlie the associations observed across these physical and mental health traits. Future experimental work will be essential to directly ascertain how CADM2‐AS2 influences CADM2 gene regulation and the resultant phenotypic outcomes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Morris, Mark E S Bailey, Damiano Baldassarre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in CADM2 as a link between psychological traits and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43861-9"}], "href": "https://doi.org/10.1038/s41598-019-43861-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31089183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31089183"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rona J Strawbridge, Joey Ward, Breda Cullen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-017-0079-1"}], "href": "https://doi.org/10.1038/s41398-017-0079-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29391395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29391395"}]}]}]}