{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent multi‐cancer studies have revealed that CADM3‑AS1, a long noncoding RNA, is aberrantly expressed in several tumor types and may contribute to cancer development and progression. In bladder cancer, large‐scale profiling of lncRNAs demonstrated pronounced dysregulation of many transcripts, with those like CADM3‑AS1 being potentially involved in key regulatory networks—such as the p53 signaling and cell cycle pathways—that affect the expression of protein‐coding genes (also linked to propanoate metabolism) and thereby promote tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in breast cancer, inclusion of CADM3‑AS1 in a multi‑lncRNA signature was associated with patient survival, indicating that its expression may help stratify patients into prognostically distinct groups."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, integrative analyses across diverse cancer types have identified CADM3‑AS1 as one of several lncRNAs under selective pressure with significant associations with mortality risk, underscoring its potential functional role in neoplasia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma, CADM3‑AS1 appears among newly identified prognostic markers that may be linked to cancer‐related biological processes, further supporting its potential as a biomarker and a candidate therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi-Ping Zhu, Xiao-Jie Bian, Ding-Wei Ye, et al. 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