CALHM4 Gene

Name calcium homeostasis modulator family member 4
Description Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Members of the calcium homeostasis modulator (CALHM) family exhibit diverse tissue‐specific functions. While CALHM1 has been characterized as a voltage‐ and Ca²⁺‑gated ion channel involved in neuronal excitability and ATP release from taste bud cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", CALHM4 appears to have a distinct role in placental physiology. In the human placenta, CALHM4 (along with CALHM2 and CALHM6) is highly expressed and is upregulated during trophoblast differentiation, suggesting that it may contribute to the regulated transport of ions and signaling molecules essential for fetal development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Cryo‐EM studies reveal that CALHM4 assembles into decameric and undecameric complexes that form a large cylindrical pore; within this pore, lipids are arranged in a bilayer‐like disposition. This structural configuration contrasts with the conical pore adopted by CALHM6, implying that differences in pore geometry—and thus channel gating and permeability—may underlie unique functional roles for each CALHM paralog in controlling placental transport processes. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhongming Ma, Jessica E Tanis, Akiyuki Taruno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium homeostasis modulator (CALHM) ion channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-015-1757-6"}], "href": "https://doi.org/10.1007/s00424-015-1757-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26603282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26603282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Katarzyna Drożdżyk, Marta Sawicka, Maria-Isabel Bahamonde-Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structures and functional properties of CALHM channels of the human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.55853"}], "href": "https://doi.org/10.7554/eLife.55853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32374262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32374262"}]}]}]}
NCBI Gene ID 221301
API
Download Associations
Predicted Functions View CALHM4's ARCHS4 Predicted Functions.
Co-expressed Genes View CALHM4's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View CALHM4's ARCHS4 Predicted Functions.

Functional Associations

CALHM4 has 494 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for CALHM4 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of CALHM4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of CALHM4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with CALHM4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with CALHM4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with CALHM4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by CALHM4 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of CALHM4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with CALHM4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of CALHM4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of CALHM4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of CALHM4 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of CALHM4 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of CALHM4 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of CALHM4 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of CALHM4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of CALHM4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with CALHM4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.