CAMK1 Gene

Name	calcium/calmodulin-dependent protein kinase I
Description	Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Calcium/calmodulin‐dependent protein kinase I (CaMKI) plays diverse roles in cellular signaling that are highly context dependent. In neuronal cells, CaMKI is activated in response to calcium influx, where it is required for the activation of extracellular signal–regulated kinases (ERKs) and the promotion of neurite outgrowth via Ras‐dependent signaling (1). In addition, CaMKI phosphorylates targets such as MARK2, thereby favoring neurite extension and neuronal differentiation (6), and it has been identified as a modifier of tau-induced neurotoxicity (4). In endocrine tissues, CaMKI mediates the derepression of the follicle-stimulating hormone β-subunit gene in gonadotropes by phosphorylating class IIa histone deacetylases, which enables expression of FSHβ (5). Moreover, in Leydig cells the CaMKI pathway cooperates with other cAMP-responsive mechanisms to regulate transcription factors such as NUR77 and MEF2, ultimately influencing steroidogenesis (9,10,11). Beyond differentiation, CaMKI modulates metabolic processes as variants in the CDC123/CAMK1D locus associate with reduced beta-cell function and insulin secretion, linking it to type 2 diabetes risk (2). In the hematopoietic system and in acute myeloid leukemia (AML), CaMKI is recruited by the LAIR1–SHP-1 complex to activate CREB, a signaling cascade that is essential for AML stem cell survival and self-renewal (3). Furthermore, CaMKI phosphorylates neuronal nitric-oxide synthase (nNOS) on Ser741 to inhibit its activity, thereby modulating nitric oxide production (12). In cancer cells, including lung and ovarian models, CaMKI functions as part of a signaling axis that influences cell proliferation and chemoresistance (8,13). Finally, increased intracellular Ca²⁺ associated with loss of SLC26A2 in adrenal cells upregulates CAMK1 expression and contributes to the chronic regulation of aldosterone biosynthesis (14). Collectively, these studies highlight CaMKI as a multifaceted kinase, serving as a pivotal mediator in processes ranging from neuronal differentiation and survival to hormone production and oncogenic signaling.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Citations:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "John M Schmitt, Gary A Wayman, Naohito Nozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium activation of ERK mediated by calmodulin kinase I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401501200"}], "href": "https://doi.org/10.1074/jbc.M401501200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15150258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15150258"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Niels Grarup, Gitte Andersen, Nikolaj T Krarup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db08-0436"}], "href": "https://doi.org/10.2337/db08-0436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18567820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18567820"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xunlei Kang, Zhigang Lu, Changhao Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3158"}], "href": "https://doi.org/10.1038/ncb3158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25915125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25915125"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Surendra S Ambegaokar, George R Jackson "}, {"type": "b", "children": [{"type": "t", "text": "Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr432"}], "href": "https://doi.org/10.1093/hmg/ddr432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21949350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21949350"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stefan Lim, Min Luo, Mingshi Koh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00248-07"}], "href": "https://doi.org/10.1128/MCB.00248-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17371839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17371839"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nataliya V Uboha, Marc Flajolet, Angus C Nairn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0725-07.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.0725-07.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17442826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17442826"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Christina R Kahl, Anthony R Means "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312543200"}], "href": "https://doi.org/10.1074/jbc.M312543200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14754892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14754892"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaoye Liu, Xiaoting Yu, Jingjing Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4217"}], "href": "https://doi.org/10.18632/oncotarget.4217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26056041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26056041"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Luc J Martin, Nicolas Boucher, Bassam El-Asmar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Androl (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2164/jandrol.108.006387"}], "href": "https://doi.org/10.2164/jandrol.108.006387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18835829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18835829"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Akira Uruno, Ken Matsuda, Naoya Noguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/JME-10-0088"}], "href": "https://doi.org/10.1677/JME-10-0088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21106862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21106862"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Caroline Daems, Luc J Martin, Catherine Brousseau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2013-1407"}], "href": "https://doi.org/10.1210/me.2013-1407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24694307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24694307"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tao Song, Naoya Hatano, Mariko Horii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.05.083"}], "href": "https://doi.org/10.1016/j.febslet.2004.05.083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15251453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15251453"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hideaki Tsuyoshi, Makoto Orisaka, Yuko Fujita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-06965-4"}], "href": "https://doi.org/10.1186/s12885-020-06965-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32448194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32448194"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ariadni Spyroglou, Tarik Bozoglu, Rajesh Rawal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.113.02504"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.113.02504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24591336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24591336"}]}]}]}
Synonyms	CAMKI
Proteins	KCC1A_HUMAN
NCBI Gene ID	8536
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CAMK1 has 6,180 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for CAMK1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CAMK1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CAMK1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAMK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAMK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CAMK1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CAMK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CAMK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAMK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CAMK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAMK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAMK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CAMK1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAMK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CAMK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CAMK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CAMK1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CAMK1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAMK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CAMK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CAMK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CAMK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CAMK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CAMK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CAMK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CAMK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CAMK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAMK1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CAMK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CAMK1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CAMK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CAMK1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CAMK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate CAMK1 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CAMK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CAMK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CAMK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CAMK1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAMK1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CAMK1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CAMK1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CAMK1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.