CAMLG Gene

Name	calcium modulating ligand
Description	The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Calcium‐modulating cyclophilin ligand (CAML) is a multifunctional protein that regulates intracellular calcium dynamics, receptor trafficking, and diverse signal‐transduction pathways. CAML mediates host transcriptional responses by linking upstream signals to activation of nuclear factor of activated T cells (NFAT). For example, during Toxoplasma gondii infection, the parasite effector protein GRA6 specifically engages CAML to activate NFAT4, thereby modulating host immune responses and enhancing parasite virulence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, CAML interacts with the angiotensin II receptor–associated protein (ATRAP) to modulate the calcineurin–NFAT pathway, which impacts vascular signaling and helps prevent vascular smooth muscle cell senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " CAML also plays a key role in receptor recycling. It associates with the epidermal growth factor receptor (EGFR) to ensure efficient recycling of internalized receptors, thereby sustaining proliferative signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and it is required for the proper recycling of endocytosed γ2 subunit‐containing GABA(A) receptors, which is essential for maintaining inhibitory synaptic transmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, CAML is crucial for lymphocyte development. In T cells, it interacts with the kinase p56lck and helps regulate its subcellular distribution, thus fine‑tuning T cell receptor signaling and contributing to appropriate thymic selection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In epithelial cells of the kidney, CAML interacts with fibrocystin, suggesting a role in integrating intracellular calcium signaling for proper renal function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond these signaling roles, CAML is also an integral component of the machinery that inserts tail‑anchored proteins into the endoplasmic reticulum membrane. Acting as a mammal‑specific receptor for the ATPase TRC40, CAML (together with WRB) drives the efficient membrane insertion of a subset of tail‑anchored proteins, a process fundamental for cellular proteostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, additional studies have revealed that CAML interacts with proteins involved in the regulation of apoptosis (via its binding to IEX‑1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and with Basigin in melanoma cells to regulate intracellular Ca<sup>2+</sup> levels, which may influence tumor invasiveness and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that CAML is a pivotal regulator of calcium‐dependent signaling and receptor trafficking. By integrating signals from diverse receptors and interacting with multiple partners, CAML coordinates cellular processes ranging from receptor recycling and immune cell development to the regulation of apoptosis and protein quality control.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ji Su Ma, Miwa Sasai, Jun Ohshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20131272"}], "href": "https://doi.org/10.1084/jem.20131272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25225460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25225460"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shaodong Guo, Marco Lopez-Ilasaca, Victor J Dzau "}, {"type": "b", "children": [{"type": "t", "text": "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500296200"}], "href": "https://doi.org/10.1074/jbc.M500296200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15668245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15668245"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li-Juan Min, Masaki Mogi, Kouichi Tamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2009.09.006"}], "href": "https://doi.org/10.1016/j.yjmcc.2009.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19769983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19769983"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David D Tran, Helen R Russell, Shari L Sutor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAML is required for efficient EGF receptor recycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1534-5807(03)00207-7"}], "href": "https://doi.org/10.1016/s1534-5807(03"}, {"type": "t", "text": "00207-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12919676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12919676"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xu Yuan, Jun Yao, David Norris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2008.03.002"}], "href": "https://doi.org/10.1016/j.mcn.2008.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18424167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18424167"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "David D Tran, Contessa E Edgar, Karin L Heckman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CAML is a p56Lck-interacting protein that is required for thymocyte development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2005.06.006"}], "href": "https://doi.org/10.1016/j.immuni.2005.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16111633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16111633"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Junko Nagano, Kenichiro Kitamura, Kristine M Hujer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.10.022"}], "href": "https://doi.org/10.1016/j.bbrc.2005.10.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16243292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16243292"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yasunori Yamamoto, Toshiaki Sakisaka "}, {"type": "b", "children": [{"type": "t", "text": "Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.08.028"}], "href": "https://doi.org/10.1016/j.molcel.2012.08.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23041287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23041287"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Rajiv Kumar, Ward Lutz, Elena Frank, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immediate early gene X-1 interacts with proteins that modulate apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.09.006"}], "href": "https://doi.org/10.1016/j.bbrc.2004.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15451437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15451437"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tingting Long, Juan Su, Wen Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2013.07.019"}], "href": "https://doi.org/10.1016/j.canlet.2013.07.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23879967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23879967"}]}]}]}
Synonyms	CAML, GET2
Proteins	CAMLG_HUMAN
NCBI Gene ID	819
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CAMLG has 6,524 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for CAMLG from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CAMLG Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAMLG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CAMLG gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CAMLG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CAMLG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAMLG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CAMLG gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAMLG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAMLG gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CAMLG gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAMLG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CAMLG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CAMLG protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CAMLG gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAMLG gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CAMLG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CAMLG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CAMLG gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CAMLG protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CAMLG gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CAMLG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CAMLG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CAMLG protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CAMLG protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CAMLG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CAMLG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CAMLG protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAMLG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CAMLG gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CAMLG gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CAMLG protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CAMLG gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for CAMLG protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CAMLG gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CAMLG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CAMLG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CAMLG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CAMLG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CAMLG protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CAMLG gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAMLG gene from the ENCODE Transcription Factor Binding Site Profiles dataset.