{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative analyses of diverse diseases have revealed critical roles for long noncoding RNAs in modulating gene expression and disease progression. Notably, in the context of HBV‐associated hepatocellular carcinoma, CAPN10‑AS1 has emerged as a promising diagnostic and prognostic biomarker. In one comprehensive study, CAPN10‑AS1 was identified among five optimal lncRNA biomarkers that distinguished tumor from adjacent tissues, with its expression strongly correlated with a network of 105 differentially expressed mRNAs. Functional annotation of these co‐expressed genes implicated key pathways—most notably the Jak‑STAT signaling pathway and retinol metabolism—that may underlie its involvement in hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While additional studies have advanced our understanding of RNA metabolism, cancer driver identification, and tissue responses in chronic conditions"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ", CAPN10‑AS1 specifically stands out in the HBV‑associated HCC setting. Its differential expression and co‐regulation with cancer‐associated mRNAs suggest that it may influence key oncogenic signaling cascades, providing a new molecular handle for early detection and potential therapeutic targeting in liver cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yonghua Mou, Dongguo Wang, Renwei Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of long noncoding RNAs biomarkers in patients with hepatitis B virus-associated hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181424"}], "href": "https://doi.org/10.3233/CBM-181424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29991128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29991128"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Toomas Silla, Manfred Schmid, Yuhui Dou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz1238"}], "href": "https://doi.org/10.1093/nar/gkz1238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31950173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31950173"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenbin Zhou, Zhangxiang Zhao, Ruiping Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of driver copy number alterations in diverse cancer types and application in drug repositioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12112"}], "href": "https://doi.org/10.1002/1878-0261.12112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28719033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28719033"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eri Takematsu, Adrianne Spencer, Jeff Auster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0225267"}], "href": "https://doi.org/10.1371/journal.pone.0225267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32084158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32084158"}]}]}]}