{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CARD8‐AS1 is emerging as a multifunctional long non‐coding RNA with potential roles in tumor progression across multiple cancer types. In ovarian cancer, CARD8‐AS1 was identified as one of several lncRNAs significantly correlated with overall patient survival, suggesting that it may serve as a prognostic biomarker and a component in gene co‐expression networks relevant to disease outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung adenocarcinoma, CARD8‐AS1 was incorporated into an oncosis‐based risk assessment model, where its inclusion helped to stratify patients according to survival outcomes and tumor immune activity, implying that this lncRNA might contribute not only to non‐apoptotic cell death processes but also to the modulation of tumor immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in glioma, CARD8‐AS1 was shown to regulate the metastatic potential of cancer cells in vitro and was part of a signature predictive of patient prognosis. Its oncogenic function in this context reinforces its candidacy as a biomarker for tumor progression and potential therapeutic targeting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these studies support the notion that CARD8‐AS1 functions as an oncogenic regulator—with measurable impact on survival, tumor cell metastasis, and the modulation of tumor immunity—across ovarian cancer, lung adenocarcinoma, and glioma. Its involvement in key molecular networks underscores its potential as both a prognostic biomarker and a therapeutic target in personalized cancer management."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Na Li, Xianquan Zhan "}, {"type": "b", "children": [{"type": "t", "text": "Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EPMA J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13167-019-00175-0"}], "href": "https://doi.org/10.1007/s13167-019-00175-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31462944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31462944"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hang Chen, Chongchang Zhou, Zeyang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of an algorithm based on oncosis-related LncRNAs comprising the molecular subtypes and a risk assessment model in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24461"}], "href": "https://doi.org/10.1002/jcla.24461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35476781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35476781"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyu Lin, Tiantongfei Jiang, Jing Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Transcriptome Transition Associates Long Noncoding RNAs with Glioma Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2018.10.009"}], "href": "https://doi.org/10.1016/j.omtn.2018.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30472640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30472640"}]}]}]}