{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although several of the provided abstracts address the roles of long non‐coding RNAs (lncRNAs) in cancer susceptibility and progression, none of them specifically mention or investigate CASC22. For instance, one study examined H19 polymorphisms and their association with breast cancer risk"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while another focused on a lincRNA (ENST00000515084) whose polymorphism influences tumor growth by altering miRNA binding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " A separate investigation analyzed several lncRNA tagSNPs in the context of breast cancer susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, the fourth abstract presented a phylogenetic study of bark beetles, which is unrelated to human lncRNA function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while these studies collectively highlight that lncRNAs can impact tumorigenesis through modulation of gene expression, cellular proliferation, and receptor status via genetic variations, none of the abstracts provide insights into the function of CASC22. Consequently, the specific role of CASC22 remains to be characterized, and further research will be necessary to elucidate its contribution to cancer biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zongjiang Xia, Rui Yan, Fujiao Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000002771"}], "href": "https://doi.org/10.1097/MD.0000000000002771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26886624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26886624"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Na Li, Ping Zhou, Jian Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0098251"}], "href": "https://doi.org/10.1371/journal.pone.0098251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24879036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24879036"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tao Xu, Xiu-Xiu Hu, Xiang-Xiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between SNPs in Long Non-coding RNAs and the Risk of Female Breast Cancer in a Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.18055"}], "href": "https://doi.org/10.7150/jca.18055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28607590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28607590"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sarah M Smith, Anthony I Cognato "}, {"type": "b", "children": [{"type": "t", "text": "A taxonomic monograph of Nearctic Scolytus Geoffroy (Coleoptera, Curculionidae, Scolytinae)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zookeys (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3897/zookeys.450.7452"}], "href": "https://doi.org/10.3897/zookeys.450.7452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25408617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25408617"}]}]}]}