{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CASK‑AS1 is a long noncoding RNA that has been implicated as a key regulatory molecule in the development and progression of distinct human diseases via its role in competing endogenous RNA (ceRNA) networks. In laryngeal squamous cell carcinoma (LSCC), CASK‑AS1 is one of several lncRNAs that engage in a ceRNA network, likely interacting with specific microRNAs (e.g., has‑mir‑210) to modulate the expression of target mRNAs involved in processes such as extracellular matrix organization, calcium signaling, and metabolism. This dysregulation is associated with patient prognosis, thereby positioning CASK‑AS1 as a potential prognostic biomarker and therapeutic target in LSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in lumbar disc degeneration (LDD), CASK‑AS1 has been identified among a group of key lncRNAs that are differentially expressed in affected tissues. Its involvement in the ceRNA regulatory network suggests that it may regulate cellular components and gene expression patterns that contribute to the degenerative processes, including negative regulation of metabolic processes. This finding further supports the potential utility of CASK‑AS1 as a candidate therapeutic target and molecular marker in LDD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted regulatory roles of CASK‑AS1 within ceRNA networks across different pathological conditions, highlighting its promise as both a biomarker for disease prognosis and a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuehui Liu, Fan Ye "}, {"type": "b", "children": [{"type": "t", "text": "Construction and integrated analysis of crosstalking ceRNAs networks in laryngeal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7380"}], "href": "https://doi.org/10.7717/peerj.7380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31367490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31367490"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y-H Zhang, J Song, L Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotech Histochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10520295.2019.1622782"}], "href": "https://doi.org/10.1080/10520295.2019.1622782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31271316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31271316"}]}]}]}