{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long non‐coding RNA CATIP-AS1 appears to play a tumor suppressive role in thyroid cancer. In thyroid cancer tissues and cells, CATIP-AS1 is significantly downregulated, and its lower expression is associated with an unfavorable clinical outcome (1). Functional studies demonstrate that restoring CATIP-AS1 expression leads to the inhibition of cell proliferation, migration, and epithelial-mesenchymal transition, while promoting apoptosis. Mechanistically, CATIP-AS1 acts as a molecular sponge for miR-515-5p, thereby relieving the microRNA’s repressive effect on Smad4 and ultimately modulating pathways involved in cell growth and metastasis (1). In addition, expression profiling of thyroid cancer samples has identified CATIP-AS1 among a set of downregulated long non-coding RNAs that correlate with longer disease-free survival, underscoring its potential as a prognostic biomarker and a promising therapeutic target (2)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fujian Qi, Ji'Ao Tang, Zhenling Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CATIP antisense RNA 1 (lncRNA CATIP-AS1) downregulation contributes to the progression and metastasis of thyroid cancer via epithelial-mesenchymal transition (EMT) pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2047400"}], "href": "https://doi.org/10.1080/21655979.2022.2047400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35264071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35264071"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuansheng Rao, Haiying Liu, Xiaojuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Analysis Identifies Differently Expressed lncRNAs as Novel Biomarkers for the Prognosis of Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3651051"}], "href": "https://doi.org/10.1155/2020/3651051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32377223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32377223"}]}]}]}