CAV2 Gene

Name	caveolin 2
Description	The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Caveolin‐2 (CAV2) is emerging as a multifunctional protein that contributes to the organization of specialized membrane microdomains and to a variety of tissue‐specific physiological and pathological processes. In the heart and eye, genetic variation in the CAV1/CAV2 locus is associated with alterations in atrial and atrioventricular conduction as well as in the development of primary open‐angle glaucoma, consistent with its expression in cardiac developmental structures and in the trabecular meshwork and retinal ganglion cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the lung, studies in caveolin‐2–null mice have revealed that loss of CAV2 selectively destabilizes caveolar components in the pulmonary parenchyma, leading to alveolar septal thickening and hypercellularity, which underscores a unique role for CAV2 in maintaining normal lung architecture independent of CAV1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, CAV2 contributes to the formation of specialized lipid microdomains at the endoplasmic reticulum, where it colocalizes with sigma‑1 receptors on ER‐associated lipid droplets, suggesting a role in intracellular lipid compartmentalization and signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " CAV2 further participates in host–pathogen interactions by facilitating the clathrin‐ and caveolin‐dependent endocytic internalization of bacterial ligands during rickettsial invasion of nonphagocytic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer biology, CAV2 has been identified as a downstream target of oncogenic pathways. For instance, in bladder and prostate carcinomas, E2F3 overexpression is linked to enhanced levels of CAV2, which may contribute to increased tumor proliferation and aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, in renal cell carcinoma, loss of the tumor‐suppressive microRNA miR‑218 leads to de‐repression of CAV2, with resultant upregulation promoting cell migration and invasion via dysregulation of the focal adhesion pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in esophageal squamous cell carcinoma, higher immunostaining for CAV2 correlates with advanced tumor stage, invasiveness, and poorer patient survival"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while PPARγ agonists also induce increased expression of CAV2 in breast cancer cells, implicating it as a mediator of differentiation‐related phenotypic changes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, as a constituent of caveolar complexes in smooth muscle and other contractile tissues, CAV2 partners with caveolin‐1 to modulate ion channel functions—such as the regulation of maxi‑K channel activity in myometrial cells—and is found in cholesterol‑rich lipid rafts associated with receptors that govern rapid signal transduction events"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these findings illustrate that CAV2 plays diverse roles in cell signaling, membrane organization, and disease pathogenesis across multiple organ systems.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Arne Pfeufer, Charlotte van Noord, Kristin D Marciante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of PR interval."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.517"}], "href": "https://doi.org/10.1038/ng.517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20062060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20062060"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gudmar Thorleifsson, G Bragi Walters, Alex W Hewitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.661"}], "href": "https://doi.org/10.1038/ng.661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20835238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20835238"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Janey L Wiggs, Jae Hee Kang, Brian L Yaspan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddr382"}], "href": "https://doi.org/10.1093/hmg/ddr382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21873608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21873608"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Babak Razani, Xiao Bo Wang, Jeffery A Engelman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.7.2329-2344.2002"}], "href": "https://doi.org/10.1128/MCB.22.7.2329-2344.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11884617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11884617"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Teruo Hayashi, Tsung-Ping Su "}, {"type": "b", "children": [{"type": "t", "text": "Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.103.051284"}], "href": "https://doi.org/10.1124/jpet.103.051284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12730355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12730355"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yvonne G Y Chan, Marissa M Cardwell, Timothy M Hermanas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1462-5822.2008.01279.x"}], "href": "https://doi.org/10.1111/j.1462-5822.2008.01279.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19134120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19134120"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "A Y Olsson, A Feber, S Edwards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209854"}], "href": "https://doi.org/10.1038/sj.onc.1209854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16909110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16909110"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Takeshi Yamasaki, Naohiko Seki, Hirofumi Yoshino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Urol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.juro.2013.02.089"}], "href": "https://doi.org/10.1016/j.juro.2013.02.089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23454155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23454155"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Takuya Ando, Hideyuki Ishiguro, Masahiro Kimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17671707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17671707"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Elke Burgermeister, Lilach Tencer, Mordechai Liscovitch "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206625"}], "href": "https://doi.org/10.1038/sj.onc.1206625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12813462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12813462"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Adam M Brainard, Andrea J Miller, Jeffrey R Martens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00399.2004"}], "href": "https://doi.org/10.1152/ajpcell.00399.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15703204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15703204"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dragoslava Zivadinovic, Cheryl S Watson "}, {"type": "b", "children": [{"type": "t", "text": "Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr959"}], "href": "https://doi.org/10.1186/bcr959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15642162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15642162"}]}]}]}
Synonyms	CAV
Proteins	CAV2_HUMAN
NCBI Gene ID	858
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CAV2 has 10,493 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for CAV2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CAV2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAV2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAV2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CAV2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CAV2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CAV2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CAV2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAV2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CAV2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAV2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CAV2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CAV2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CAV2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAV2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CAV2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CAV2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CAV2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CAV2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CAV2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CAV2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CAV2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CAV2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CAV2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CAV2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CAV2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CAV2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CAV2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CAV2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CAV2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CAV2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CAV2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CAV2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CAV2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CAV2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CAV2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CAV2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CAV2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CAV2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CAV2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CAV2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CAV2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.