| Name | caveolae associated protein 3 |
| Description | The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CAVIN3, also known as PRKCDBP or hSRBC, is a multifunctional component of caveolae that plays several critical roles in cellular homeostasis. As part of a hetero‐oligomeric complex with other cavin proteins (notably cavin‐1 and cavin‐2), CAVIN3 helps specify caveolar coat structure and promotes dynamic remodeling of caveolae at the plasma membrane."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition to its architectural contribution, CAVIN3 functions as a signaling adaptor that regulates key pathways. It facilitates efficient ERK activation by tethering caveolae to the membrane skeleton—thereby promoting pro‐apoptotic and anti‐proliferative signals—while its loss shifts the balance toward enhanced Akt signaling, metabolic reprogramming, and decreased apoptotic sensitivity, a pattern that underlies its tumor suppressor role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, by interacting with caveolin‐1 upon recruitment by cavin‐1, CAVIN3 regulates caveolar budding and turnover; its deficiency leads to an increased population of abnormally stable caveolae at the cell surface."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Under conditions of stress, such as UV exposure, CAVIN3 can be released from caveolae to interact with intracellular targets—including PP1α—to modulate apoptotic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In parallel, evidence shows that CAVIN3 directly interacts with key DNA repair proteins such as BRCA1, thereby linking caveolar dynamics with genomic maintenance; loss of CAVIN3 diminishes BRCA1 levels and can sensitize cells to PARP inhibition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Together, these studies support a model in which CAVIN3 integrates caveolae structure with signal transduction and stress response pathways, and its dysregulation may contribute to tumorigenesis and therapeutic resistance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michele Bastiani, Libin Liu, Michelle M Hill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200903053"}], "href": "https://doi.org/10.1083/jcb.200903053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546242"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yann Gambin, Nicholas Ariotti, Kerrie-Ann McMahon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.01434"}], "href": "https://doi.org/10.7554/eLife.01434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24473072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24473072"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Victor J Hernandez, Jian Weng, Peter Ly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cavin-3 dictates the balance between ERK and Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.00905"}], "href": "https://doi.org/10.7554/eLife.00905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24069528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24069528"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jagan Mohan, Björn Morén, Elin Larsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.161463"}], "href": "https://doi.org/10.1242/jcs.161463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25588833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25588833"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-11111-1"}], "href": "https://doi.org/10.1038/s41467-019-11111-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31332168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31332168"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kerrie-Ann McMahon, David A Stroud, Yann Gambin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.61407"}], "href": "https://doi.org/10.7554/eLife.61407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34142659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34142659"}]}]}]}
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| NCBI Gene ID | 112464 |
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CAVIN3 has 2,403 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 37 datasets.
Click the + buttons to view associations for CAVIN3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CAVIN3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of CAVIN3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with CAVIN3 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with CAVIN3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CAVIN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of CAVIN3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing CAVIN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with CAVIN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of CAVIN3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by CAVIN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving CAVIN3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with CAVIN3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CAVIN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CAVIN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with CAVIN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing CAVIN3 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing CAVIN3 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by CAVIN3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by CAVIN3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of CAVIN3 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CAVIN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of CAVIN3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with CAVIN3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with CAVIN3 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of CAVIN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of CAVIN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of CAVIN3 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of CAVIN3 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by CAVIN3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of CAVIN3 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of CAVIN3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CAVIN3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CAVIN3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CAVIN3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CAVIN3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with CAVIN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving CAVIN3 protein from the WikiPathways Pathways 2024 dataset. | |
