{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent transcriptome profiling study of Alzheimer’s disease (AD) that explored the dysregulation of long non‐coding RNAs (lncRNAs) and protein-coding genes (PCGs) in brain tissue, a wide array of lncRNAs were identified as either up-regulated or down-regulated in AD relative to normal brain specimens (1). Although the study provided valuable insights into the potential roles of several lncRNAs in AD pathogenesis—highlighting candidates such as RP3-522J7, MIR3180-2, and MIR3180-3 due to their co-expression with known AD risk genes and enrichment in brain-related functions—it did not specifically address or characterize the function of the lncRNA CCDC13-AS1. Consequently, within the context of this analysis, the function of CCDC13-AS1 remains undetermined, and its role in AD or related biological processes has yet to be elucidated.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Further investigations will be necessary to define whether CCDC13-AS1 contributes to the molecular mechanisms underlying AD pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuchen Shi, Hui Liu, Changbo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic Analyses for Identification and Prioritization of Genes Associated With Alzheimer's Disease in Humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Bioeng Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fbioe.2020.00031"}], "href": "https://doi.org/10.3389/fbioe.2020.00031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32154224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32154224"}]}]}]}