| Name | coiled-coil domain containing 140 |
| Description | This gene encodes a protein that appears to be restricted to select higher primate species. This protein contains a C-terminal coiled-coil domain, which is a versatile structural motif consisting of multiple amphipathic alpha-helices that twist around each other to form a supercoil. [provided by RefSeq, Aug 2011] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMatrix metalloproteinase‐11 (MMP11) is emerging as a key protease in the regulation of extracellular matrix (ECM) remodeling in adipose tissue. It cleaves the native α3 chain of collagen VI, a process essential for proper ECM folding, tissue cohesion, and adipocyte function. Loss of MMP11 is associated with adipocyte hypertrophy and altered fat depot organization, underscoring its critical role in adipose tissue development and homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its function in adipose tissue, MMP11 exerts important local paracrine effects during postnatal mammary gland morphogenesis by promoting ductal branching, epithelial invasion, and stromal-epithelial interactions. Its activity is modulated by factors such as the glycosylated form of the plasma membrane glycoprotein CD147, which, when altered, can downregulate MMP11 expression and consequently diminish cell adhesion and metastatic potential. These findings implicate MMP11 in both normal developmental processes and in the invasive behavior of cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the systemic level, MMP11 overexpression is linked with metabolic reprogramming that protects against type 2 diabetes—partly by shifting energy metabolism and enhancing IGF1/AKT/FOXO1 signaling—whereas its deficiency is associated with metabolic syndrome features. Paradoxically, host-derived MMP11 also shapes metastatic outcomes by fostering the early emergence and accelerated growth of lung metastases while simultaneously limiting the overall dissemination of cancer cells. In addition, MMP11 expression by macrophages resident in remodeling tissues (such as during thymocyte clearance) further supports its multifaceted role in tissue homeostasis and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "H R Lijnen, Hoef B Van, L Frederix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adipocyte hypertrophy in stromelysin-3 deficient mice with nutritionally induced obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11916087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11916087"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "E R Motrescu, S Blaise, N Etique, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.218"}], "href": "https://doi.org/10.1038/onc.2008.218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18622425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18622425"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Jia, Huimin Zhou, Shujing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deglycosylation of CD147 down-regulates Matrix Metalloproteinase-11 expression and the adhesive capability of murine hepatocarcinoma cell HcaF in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15216540600719580"}], "href": "https://doi.org/10.1080/15216540600719580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Jia, Jun Cao, Wei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD147 depletion down-regulates matrix metalloproteinase-11, vascular endothelial growth factor-A expression and the lymphatic metastasis potential of murine hepatocarcinoma Hca-F cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2007.06.007"}], "href": "https://doi.org/10.1016/j.biocel.2007.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17693120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17693120"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J Tan, E Buache, F Alpy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal matrix metalloproteinase-11 is involved in the mammary gland postnatal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.434"}], "href": "https://doi.org/10.1038/onc.2013.434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24141782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24141782"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chikako Odaka, Shinji Izumiyama "}, {"type": "b", "children": [{"type": "t", "text": "Expression of stromelysin-3 (matrix metalloproteinase-11) in macrophages of murine thymus following thymocyte apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2005.06.011"}], "href": "https://doi.org/10.1016/j.cellimm.2005.06.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16165118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16165118"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Daniela Peruzzi, Federica Mori, Antonella Conforti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MMP11: a novel target antigen for cancer immunotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-3226"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-3226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19509157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19509157"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "David Brasse, Carole Mathelin, Khadija Leroux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase 11/stromelysin-3 exerts both activator and repressor functions during the hematogenous metastatic process in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25309"}], "href": "https://doi.org/10.1002/ijc.25309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20209494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20209494"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep25140"}], "href": "https://doi.org/10.1038/srep25140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27126782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27126782"}]}]}]}
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| Proteins | CC140_HUMAN |
| NCBI Gene ID | 151278 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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CCDC140 has 916 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 32 datasets.
Click the + buttons to view associations for CCDC140 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of CCDC140 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of CCDC140 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of CCDC140 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of CCDC140 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC140 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of CCDC140 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with CCDC140 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of CCDC140 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with CCDC140 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with CCDC140 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at CCDC140 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC140 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of CCDC140 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with CCDC140 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of CCDC140 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CCDC140 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CCDC140 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with CCDC140 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with CCDC140 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of CCDC140 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of CCDC140 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of CCDC140 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of CCDC140 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of CCDC140 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain CCDC140 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of CCDC140 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of CCDC140 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at CCDC140 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of CCDC140 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of CCDC140 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of CCDC140 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with CCDC140 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
