{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators in diverse cellular processes ranging from viral infection to immune modulation and cell death. Although earlier studies characterized lncRNAs such as LINC00173 in the context of HIV‐1 infection"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and developed computational frameworks to reveal lncRNA functions in carcinogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", recent evidence specifically implicates "}, {"type": "b", "children": [{"type": "t", "text": "CCDC18‑AS1"}]}, {"type": "t", "text": " as an immune‐related molecule with potential diagnostic and prognostic utility. In psoriasis, for example, "}, {"type": "b", "children": [{"type": "t", "text": "CCDC18‑AS1"}]}, {"type": "t", "text": " was identified as one of several diagnostic lncRNA biomarkers exhibiting strong correlations with the infiltration of activated memory CD4+ T cells, activated myeloid dendritic cells, neutrophils, M1 macrophages, and T follicular helper cells, while being inversely correlated with regulatory T cells, suggesting a role in promoting a pro‐inflammatory microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in colon adenocarcinoma, "}, {"type": "b", "children": [{"type": "t", "text": "CCDC18‑AS1"}]}, {"type": "t", "text": " was incorporated into a pyroptosis‐related lncRNA signature that not only stratified patients into different risk groups based on overall survival but was also linked with variations in the immune landscape, underscoring its relevance in cell death pathways and tumor immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas S Postler, Shara N Pantry, Ronald C Desrosiers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2017.08.006"}], "href": "https://doi.org/10.1016/j.virol.2017.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28803142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28803142"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinyuan Xu, Aiai Shi, Zhilin Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capturing functional long non-coding RNAs through integrating large-scale causal relations from gene perturbation experiments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2018.08.050"}], "href": "https://doi.org/10.1016/j.ebiom.2018.08.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30177244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30177244"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feixiang Fan, Zhen Huang, Yongfeng Chen "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11018"}], "href": "https://doi.org/10.7717/peerj.11018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33732554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33732554"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fada Xia, Yuanliang Yan, Cong Shen "}, {"type": "b", "children": [{"type": "t", "text": "A Prognostic Pyroptosis-Related lncRNAs Risk Model Correlates With the Immune Microenvironment in Colon Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.811734"}], "href": "https://doi.org/10.3389/fcell.2021.811734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34966747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34966747"}]}]}]}