CCDC88A Gene

Name	coiled-coil domain containing 88A
Description	This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCDC88A, also known as GIV/Girdin, is a multifunctional signaling scaffold that integrates inputs from diverse receptors to orchestrate key cellular responses. Acting as an Akt substrate and nonreceptor guanine nucleotide exchange factor for Gαi, CCDC88A enhances actin cytoskeletal remodeling and directs the formation of structures such as lamellipodia to promote efficient cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Moreover, by facilitating the activation of the PI3K–Akt pathway and modulating receptor tyrosine kinase signaling, CCDC88A plays a prominent role in tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the central nervous system, its interactions with proteins such as DISC1 enable CCDC88A to regulate axonal development and synaptic plasticity, processes that are essential for neurogenesis and may influence vulnerability to psychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, CCDC88A-mediated signaling contributes to angiogenesis and vascular as well as fibrogenic remodeling, underscoring its role in both physiological and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, genome‐wide association studies have identified the CCDC88A locus as being associated with alcohol dependence, further highlighting the broad impact of this signaling hub on human health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Atsushi Enomoto, Hideki Murakami, Naoya Asai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akt/PKB regulates actin organization and cell motility via Girdin/APE."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2005.08.001"}], "href": "https://doi.org/10.1016/j.devcel.2005.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16139227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16139227"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ping Jiang, Atsushi Enomoto, Mayumi Jijiwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An actin-binding protein Girdin regulates the motility of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-5111"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-5111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18316593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18316593"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mikel Garcia-Marcos, Pradipta Ghosh, Marilyn G Farquhar "}, {"type": "b", "children": [{"type": "t", "text": "GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0900294106"}], "href": "https://doi.org/10.1073/pnas.0900294106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19211784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19211784"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Changsheng Lin, Jason Ear, Yelena Pavlova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2002049"}], "href": "https://doi.org/10.1126/scisignal.2002049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21954290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21954290"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "A Natsume, T Kato, S Kinjo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Girdin maintains the stemness of glioblastoma stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.466"}], "href": "https://doi.org/10.1038/onc.2011.466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22020337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22020337"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Atsushi Enomoto, Naoya Asai, Takashi Namba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2009.08.015"}], "href": "https://doi.org/10.1016/j.neuron.2009.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19778507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19778507"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tsuyoshi Nakai, Taku Nagai, Motoki Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2228-14.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.2228-14.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25378165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25378165"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tomoya Kitamura, Naoya Asai, Atsushi Enomoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1695"}], "href": "https://doi.org/10.1038/ncb1695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18264090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18264090"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Inmaculada Lopez-Sanchez, Ying Dunkel, Yoon-Seok Roh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5451"}], "href": "https://doi.org/10.1038/ncomms5451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25043713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25043713"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "J Gelernter, H R Kranzler, R Sherva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2013.145"}], "href": "https://doi.org/10.1038/mp.2013.145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24166409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24166409"}]}]}]}
Synonyms	KIAA1212, GIRDIN, GRDN, GIV, HKRP1, PEHOL
Proteins	GRDN_HUMAN
NCBI Gene ID	55704
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCDC88A has 8,538 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 125 datasets.

Click the + buttons to view associations for CCDC88A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCDC88A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC88A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC88A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCDC88A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCDC88A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCDC88A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCDC88A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC88A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCDC88A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCDC88A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CCDC88A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCDC88A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCDC88A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CCDC88A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CCDC88A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC88A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCDC88A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCDC88A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CCDC88A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCDC88A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCDC88A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCDC88A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCDC88A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCDC88A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CCDC88A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCDC88A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CCDC88A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CCDC88A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CCDC88A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CCDC88A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CCDC88A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CCDC88A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCDC88A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCDC88A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCDC88A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCDC88A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCDC88A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCDC88A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCDC88A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCDC88A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CCDC88A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.