{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent whole‐exome sequencing study in carotid paragangliomas (CPGLs) identified a set of genes exhibiting high mutation rates that may contribute to tumor initiation and progression. Among these, "}, {"type": "b", "children": [{"type": "t", "text": "CCDC89"}]}, {"type": "t", "text": "—a gene encoding a coiled‐coil domain–containing protein—was found as a potential novel player in CPGL pathogenesis. Although its precise molecular function remains to be fully elucidated, the discovery of recurrent mutations in CCDC89 in CPGLs suggests that it might be involved in key signaling pathways or structural protein interactions that affect tumor development. The involvement of CCDC89 in CPGLs was discussed alongside other genes implicated in neoplastic processes, supporting the notion that alterations in proteins with coiled‐coil domains may disrupt normal cellular homeostasis and contribute to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Other studies have highlighted the roles of coiled‐coil domain–containing proteins and their partners—such as those functioning in the regulation of basic helix–loop–helix transcription factors (e.g., via interaction with the Orange domain in proteins like HRT/Hey) and in context‐dependent repression mechanisms—as well as their broader contributions to cellular signaling, apoptosis, and stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Although these works do not directly address CCDC89, they underscore the importance of protein domains that mediate molecular interactions and cellular regulation—a concept that may also be relevant to understanding how CCDC89 mutations contribute to tumorigenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A V Snezhkina, E N Lukyanova, M S Fedorova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Novel Genes Associated with the Development of Carotid Paragangliomas]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol (Mosk) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0026898419040141"}], "href": "https://doi.org/10.1134/S0026898419040141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31397435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31397435"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Reginald Van Wayenbergh, Vincent Taelman, Bruno Pichon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.10406"}], "href": "https://doi.org/10.1002/dvdy.10406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14648848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14648848"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karen Eastwood, Chong Yin, Mohna Bandyopadhyay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-0996-x"}], "href": "https://doi.org/10.1007/s11010-011-0996-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21789514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21789514"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Barbara Maino, Maria Teresa Ciotti, Pietro Calissano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms15045596"}], "href": "https://doi.org/10.3390/ijms15045596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24694544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24694544"}]}]}]}