{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n C‐C motif chemokine ligand 14 (CCL14) is an epithelial‐derived chemokine that plays diverse roles in both homeostatic and pathological processes. In breast cancer, for example, the epigenetic JARID1B/LSD1/NuRD complex represses CCL14 expression to suppress angiogenesis and metastasis, indicating that CCL14 normally contributes to tumor progression when expressed."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the bone marrow microenvironment of myeloma, high levels of CCL14 correlate with increased infiltration and proliferation of macrophages, suggesting a role in immune cell recruitment and the polarization of tumor‐associated macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " At the maternal–fetal interface, abundant CCL14 expression in endometrial and decidual cells promotes trophoblast migration by modulating the expression of adhesion molecules and extracellular matrix components, which is critical for proper implantation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, evidence from TLR4 stimulation studies shows that CCL14 expression is regulated during innate immune responses in monocytes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in the intestinal epithelium, high constitutive expression of its human homolog contributes to mucosal defense through direct antibacterial activity—a function that is enhanced during inflammatory conditions such as inflammatory bowel disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Structural analyses have revealed that proteolytic processing of full‐length CCL14 (which normally exists as a stable dimer) into its truncated form, CCL14(9–74), yields a monomeric molecule that is functionally active and capable of potent receptor binding; furthermore, the decoy receptor D6 selectively degrades this active isoform to modulate inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, genetic studies have implicated CCL14 as a prognostic marker in hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and as a candidate locus associated with systemic lupus erythematosus, highlighting its broader relevance in both cancer and autoimmunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qian Li, Lei Shi, Bin Gui, et al. 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