| Name | cellular communication network factor 1 |
| Description | The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cyr61 (also known as CCN1) is a secreted, extracellular matrix–associated matricellular protein that plays multifaceted roles in both normal physiology and disease. Functioning as an integrin ligand, CCN1 modulates cell adhesion, migration, proliferation, and survival. In the vascular context, it is a potent angiogenic inducer that regulates endothelial cell adhesion and tubule formation—processes that are critical for vessel bifurcation and proper vascular development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Additionally, CCN1 has been identified as a direct target of canonical Wnt/β-catenin signaling in mesenchymal stem cells, where it promotes osteogenic differentiation and enhances cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In cancer, aberrant CCN1 expression is implicated in promoting tumor progression. In breast cancer, for example, its overexpression correlates with advanced stage, larger tumor size, lymph node involvement, chemotherapeutic resistance, and the acquisition of estrogen-independence—features that drive invasiveness and tumor vascularization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Similarly, elevated CCN1 levels in gliomas have been associated with higher tumor grade and poorer patient survival, underscoring its potential as a prognostic marker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings establish CCN1 as a critical regulator of integrin-mediated signaling, angiogenesis, and extracellular matrix interactions, with important implications in tissue remodeling, stem cell differentiation, and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan-E Mo, Andrew G Muntean, Chih-Chiun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CYR61 (CCN1) is essential for placental development and vascular integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.24.8709-8720.2002"}], "href": "https://doi.org/10.1128/MCB.22.24.8709-8720.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12446788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12446788"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shr-Jeng Leu, Stephen C-T Lam, Lester F Lau "}, {"type": "b", "children": [{"type": "t", "text": "Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209288200"}], "href": "https://doi.org/10.1074/jbc.M209288200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12364323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12364323"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David R Brigstock "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/a:1023823803510"}], "href": "https://doi.org/10.1023/a:1023823803510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12831056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12831056"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weike Si, Quan Kang, Hue H Luu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.8.2955-2964.2006"}], "href": "https://doi.org/10.1128/MCB.26.8.2955-2964.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16581771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16581771"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D Xie, K Nakachi, H Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2001)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11751417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11751417"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ming-Tsan Lin, Cheng-Chi Chang, Szu-Ta Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402305200"}], "href": "https://doi.org/10.1074/jbc.M402305200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15044484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15044484"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miaw-Sheue Tsai, Daphne F Bogart, Jessica M Castañeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyr61 promotes breast tumorigenesis and cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205682"}], "href": "https://doi.org/10.1038/sj.onc.1205682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12444554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12444554"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dong Xie, Dong Yin, He-Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.ccr-0659-03"}], "href": "https://doi.org/10.1158/1078-0432.ccr-0659-03"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15041728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15041728"}]}]}]}
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| NCBI Gene ID | 3491 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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CCN1 has 1,974 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.
Click the + buttons to view associations for CCN1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CCN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with CCN1 protein from the CCLE Cell Line Proteomics dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of CCN1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of CCN1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by CCN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for CCN1 protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CCN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CCN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with CCN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CCN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of CCN1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with CCN1 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with CCN1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with CCN1 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by CCN1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving CCN1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving CCN1 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving CCN1 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of CCN1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CCN1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CCN1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of CCN1 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| WikiPathways Pathways 2024 | pathways involving CCN1 protein from the WikiPathways Pathways 2024 dataset. | |
