{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A series of recent studies have identified the atypical cyclin P, also known as CNTD2 or CCNP, as an emerging oncogenic factor with multifaceted roles in cancer progression. Elevated levels of CCNP have been observed in lung and colorectal cancer tissues in comparison to adjacent normal tissue, where its overexpression is associated with enhanced cell viability, proliferation, migration, clonogenicity, and in vivo tumor growth – all of which correlate with a worse overall prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its contribution to tumor growth, CCNP plays a key role in regulating cancer cell stemness. Studies demonstrate that CCNP increases spheroid formation and upregulates the expression of both stemness markers (e.g., CD44 and CD133) and pluripotency transcription factors (e.g., SOX2, OCT4, and NANOG). This process appears to be mediated, at least in part, by activation of the WNT signaling pathway, which is crucial for maintaining stem-like properties and contributes to enhanced resistance to anticancer drugs via the induction of multidrug resistance transporters."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In additional observations, co-expression analyses in the context of Epstein–Barr virus–associated gastric carcinoma indicate that CCNP may interact with viral oncogenes, further implicating its role in cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings suggest that CCNP not only promotes tumorigenic processes but also sustains cancer stemness and chemoresistance, making it a promising prognostic biomarker and potential therapeutic target across multiple malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L Gasa, A Sanchez-Botet, E Quandt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-10770-8"}], "href": "https://doi.org/10.1038/s41598-017-10770-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28860486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28860486"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Abril Sánchez-Botet, Laura Gasa, Eva Quandt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-30307-x"}], "href": "https://doi.org/10.1038/s41598-018-30307-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30087414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30087414"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Abril Sánchez-Botet, Eva Quandt, Núria Masip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-021-00636-7"}], "href": "https://doi.org/10.1007/s13402-021-00636-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34604945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34604945"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ruiyuan Zhang, Michael J Strong, Melody Baddoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of Epstein-Barr virus genes with human gastric carcinoma transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16417"}], "href": "https://doi.org/10.18632/oncotarget.16417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28415594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28415594"}]}]}]}