CCR1 Gene

HGNC Family	G protein-coupled receptors, CD molecules (CD)
Name	chemokine (C-C motif) receptor 1
Description	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCR1 is a member of the CC‐chemokine receptor family that plays a multifaceted role in regulating immune cell migration and tissue localization. It serves as a receptor for chemokines such as MIP‑1α, where its engagement initiates signaling cascades that coordinate the trafficking of diverse leukocyte subsets—including neutrophils, monocytes, T cells, memory B cells, and natural killer T cells (for example"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the oncologic context, CCR1 contributes to tumor progression by mediating the retention and adhesion of tumor‐associated macrophages and immature myeloid cells. This chemokine‐driven cascade not only promotes pulmonary metastasis in breast cancer through stabilization of metastasis‐associated macrophages"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", but also facilitates colorectal tumor invasion by directing the accumulation of CD34⁺ immature myeloid cells at the invasive front."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In hematological malignancies, oncogenic factors such as c‑maf upregulate CCR1 alongside other targets to modulate adhesion and proliferation in multiple myeloma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, CCR1 function extends to inflammatory diseases: it is implicated in the nonredundant recruitment of neutrophils—as observed in experimental models of autoantibody‑induced arthritis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "—and contributes to the tissue homing of memory B cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Interestingly, studies in atherosclerosis models have reported that deletion of CCR1 correlates with increased plaque area and heightened T‑cell–mediated inflammation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", suggesting that under certain conditions, CCR1 signaling may also serve a protective role in vascular homeostasis. Moreover, perivascular inflammatory conditions in hypertension are associated with enhanced recruitment of CCR1‑expressing T cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, CCR1 functions as a key chemokine receptor that orchestrates the recruitment and retention of immune and inflammatory cells in both tumor microenvironments and chronic inflammatory conditions. These diverse roles make CCR1 an attractive target for therapeutic intervention across a range of pathological states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patricia Menten, Anja Wuyts, Jo Van Damme "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage inflammatory protein-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1359-6101(02)00045-x"}], "href": "https://doi.org/10.1016/s1359-6101(02"}, {"type": "t", "text": "00045-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12401480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12401480"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chang H Kim, Brent Johnston, Eugene C Butcher "}, {"type": "b", "children": [{"type": "t", "text": "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2001-12-0196"}], "href": "https://doi.org/10.1182/blood-2001-12-0196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12070001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12070001"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takanori Kitamura, Bin-Zhi Qian, Daniel Soong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20141836"}], "href": "https://doi.org/10.1084/jem.20141836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26056232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26056232"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takanori Kitamura, Kohei Kometani, Hiroki Hashida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1997"}], "href": "https://doi.org/10.1038/ng1997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17369830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17369830"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elaine M Hurt, Adrian Wiestner, Andreas Rosenwald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1535-6108(04)00019-4"}], "href": "https://doi.org/10.1016/s1535-6108(04"}, {"type": "t", "text": "00019-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14998494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14998494"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Richard C Chou, Nancy D Kim, Christian D Sadik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2010.07.018"}], "href": "https://doi.org/10.1016/j.immuni.2010.07.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20727790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20727790"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pratima Karnik, Zenar Tekeste, Thomas S McCormick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.369"}], "href": "https://doi.org/10.1038/jid.2008.369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19052558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19052558"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Götz R A Ehrhardt, Joyce T Hsu, Lanier Gartland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20050879"}], "href": "https://doi.org/10.1084/jem.20050879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16157685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16157685"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Vincent Braunersreuther, Alma Zernecke, Claire Arnaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000253886.44609.ae"}], "href": "https://doi.org/10.1161/01.ATV.0000253886.44609.ae"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17138939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17138939"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tomasz P Mikolajczyk, Ryszard Nosalski, Piotr Szczepaniak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201500088R"}], "href": "https://doi.org/10.1096/fj.201500088R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26873938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26873938"}]}]}]}
Synonyms	CD191, CMKBR1, SCYAR1, HM145, MIP1AR, CKR1, CKR-1
Proteins	CCR1_HUMAN
NCBI Gene ID	1230
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCR1 has 7,960 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for CCR1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCR1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CCR1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCR1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCR1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCR1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCR1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCR1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCR1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCR1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCR1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCR1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CCR1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCR1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCR1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CCR1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CCR1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCR1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCR1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCR1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CCR1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CCR1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCR1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCR1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCR1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCR1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCR1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CCR1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CCR1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CCR1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for CCR1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CCR1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCR1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCR1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCR1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCR1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCR1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCR1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CCR1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CCR1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CCR1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CCR1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.