CCT5 Gene

HGNC Family	Heat shock proteins
Name	chaperonin containing TCP1, subunit 5 (epsilon)
Description	The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCT5 is one of the eight subunits of the cytosolic chaperonin complex TRiC (also known as CCT), which is essential for the ATP‐dependent folding of many proteins. Studies have demonstrated that CCT5 can assemble into homo-oligomeric double-ring complexes that retain substrate refolding activity, underscoring its intrinsic chaperone function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mutations in CCT5, such as the H147R substitution identified in patients and animal models with mutilating sensory neuropathy and spastic paraplegia, impair its chaperoning ability and are associated with neurodegenerative phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, altered CCT5 expression has been implicated in cancer biology. Upregulation of CCT5 in p53-mutated breast tumors correlates with a lower response rate to docetaxel, while genomic amplification and overexpression have been identified as driver events in certain breast cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In gastric cancer, CCT5 overexpression facilitates cell migration and invasion by binding to the cytoplasmic domain of E-cadherin, consequently disrupting the E-cadherin/β-catenin complex and activating Wnt/β-catenin signaling, which promotes epithelial–mesenchymal transition and lymph node metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n CCT5 also plays a critical role in proteostasis. Its activity is necessary for proper autophagosome degradation, as depletion (together with other TRiC subunits) leads to the accumulation and aggregation of misfolded, disease-relevant proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, in models of Huntington disease, CCT5 homo-oligomers cap fibrils and sequester soluble oligomers of mutant huntingtin, thereby inhibiting pathological aggregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Elevated CCT5 expression has also been noted in sinonasal adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", further highlighting its potential involvement in tumor progression.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies reveal that CCT5 is a multifunctional chaperonin subunit whose proper assembly and activity are essential for protein folding, prevention of aggregation, and regulation of signaling pathways that impact neuronal integrity and tumor behavior.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Oksana A Sergeeva, Bo Chen, Cameron Haase-Pettingell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.443929"}], "href": "https://doi.org/10.1074/jbc.M112.443929"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23612981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23612981"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miranda P Collier, Karen Betancourt Moreira, Kathy H Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-91086-6"}], "href": "https://doi.org/10.1038/s41598-021-91086-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34158536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34158536"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Bouhouche, A Benomar, N Bouslam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2005.039230"}], "href": "https://doi.org/10.1136/jmg.2005.039230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16399879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16399879"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Oksana A Sergeeva, Meme T Tran, Cameron Haase-Pettingell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.576033"}], "href": "https://doi.org/10.1074/jbc.M114.576033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25124038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25124038"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Asako Ooe, Kikuya Kato, Shinzaburo Noguchi "}, {"type": "b", "children": [{"type": "t", "text": "Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-006-9293-x"}], "href": "https://doi.org/10.1007/s10549-006-9293-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16821082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16821082"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jichao He, Ronan P McLaughlin, Lambert van der Beek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1279-3"}], "href": "https://doi.org/10.1038/s41388-020-1279-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32235890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32235890"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yun Li, Chenying Liu, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41416-022-01747-0"}], "href": "https://doi.org/10.1038/s41416-022-01747-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35194191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35194191"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mariana Pavel, Sara Imarisio, Fiona M Menzies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCT complex restricts neuropathogenic protein aggregation via autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms13821"}], "href": "https://doi.org/10.1038/ncomms13821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27929117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27929117"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michele C Darrow, Oksana A Sergeeva, Jose M Isas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.655373"}], "href": "https://doi.org/10.1074/jbc.M115.655373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25995452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25995452"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dominique Tripodi, Sylvia Quéméner, Karine Renaudin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression profiling in sinonasal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1755-8794-2-65"}], "href": "https://doi.org/10.1186/1755-8794-2-65"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19903339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19903339"}]}]}]}
Synonyms	HEL-S-69, CCT-EPSILON, CCTE, PNAS-102, TCP-1-EPSILON
Proteins	TCPE_HUMAN
NCBI Gene ID	22948
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CCT5 has 12,341 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for CCT5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CCT5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CCT5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCT5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCT5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CCT5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CCT5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CCT5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CCT5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CCT5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCT5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CCT5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CCT5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCT5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CCT5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CCT5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CCT5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CCT5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CCT5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CCT5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with CCT5 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CCT5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CCT5 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CCT5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CCT5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CCT5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CCT5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CCT5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CCT5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CCT5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CCT5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CCT5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CCT5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CCT5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CCT5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CCT5 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CCT5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CCT5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CCT5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CCT5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CCT5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CCT5 gene from the ENCODE Histone Modification Site Profiles dataset.