HGNC Family | CD molecules (CD) |
Name | CD14 molecule |
Description | The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020] |
Summary |
{"type": "root", "children": [{"type": "t", "text": "<div>\n "}, {"type": "p", "children": [{"type": "t", "text": "\n CD14 is a multifunctional pattern recognition receptor that plays a central role in innate immunity by binding and trafficking acylated microbial products such as lipopolysaccharide (LPS) to Toll‐like receptor (TLR) signaling complexes. Structural studies reveal that human CD14 possesses an amino‐terminal pocket designed to accommodate lipid ligands, enabling the initiation of proinflammatory cascades that can be both protective and pathologic."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the central nervous system and peripheral tissues, CD14 modulates diverse disease processes. For instance, its participation in neuroimmune signaling has been linked to regulation of alcohol consumption and neuropathic pain, as loss of CD14 attenuates LPS/TLR4‐mediated nociceptive responses, while soluble CD14 derived from microglia may act to counterbalance excessive glial activation in neurodegenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer biology, CD14 expression can delineate functionally distinct cell populations, with high CD14 levels in bladder and colorectal cancer cells correlating with increased production of inflammatory mediators, recruitment of immunosuppressive myeloid cells, and ultimately, enhanced tumor growth and poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Conversely, genetic variations in the CD14 promoter have been associated with differential immune responses in conditions such as asthma, altered IgE production, and metabolic dysregulation, underscoring its influence on susceptibility to inflammatory and metabolic diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, CD14 is critical for effective TLR4-mediated responses to both exogenous (e.g., bacterial endotoxins, scorpion venom, and viral components) and endogenous ligands, serving as a co-receptor that not only amplifies inflammatory signaling through its interactions with various ligands and adaptor molecules but also regulates receptor internalization to modulate subsequent cellular responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": " Synthetic antagonists that target CD14 further underscore its therapeutic potential by competitively inhibiting ligand binding and attenuating downstream TLR4 activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while antibody-mediated ligation of CD14 can induce receptor internalization and modulate cellular sensitivity to LPS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In inflammatory conditions beyond infection, CD14-dependent signaling has been shown to contribute to the pathogenesis of ventilator-induced lung injury through interactions with endogenous ligands such as WISP1, and is a pivotal mediator in experimental cerebral malaria where its absence reduces disease severity and parasitemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Additionally, studies of apoptotic cell clearance have identified a critical role for CD14—specifically residue 11—in tethering dying cells to macrophages, a function that is extended to non-professional phagocytes in various tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, CD14 is integral to the modulation of immune cell activation, as exemplified by its requirement in lectin-induced macrophage responses wherein CD14 collaborates with TLR2 to trigger a robust proinflammatory and antimicrobial program."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " CD14’s diverse roles, spanning microbial recognition, signal amplification, receptor internalization, and immunomodulation, underpin its importance as both a biomarker and a potential therapeutic target across a range of inflammatory, infectious, and neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n</div>"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuri A Blednov, Igor Ponomarev, Chelsea Geil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Addict Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1369-1600.2010.00284.x"}], "href": "https://doi.org/10.1111/j.1369-1600.2010.00284.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21309947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21309947"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stacy L Kelley, Tiit Lukk, Satish K Nair, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1202446"}], "href": "https://doi.org/10.4049/jimmunol.1202446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23264655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23264655"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L Cao, F Y Tanga, J A Deleo "}, {"type": "b", "children": [{"type": "t", "text": "The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2008.10.004"}], "href": "https://doi.org/10.1016/j.neuroscience.2008.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18976692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18976692"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guo Nan Yin, Hyejin Jeon, Shinrye Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.22081"}], "href": "https://doi.org/10.1002/jnr.22081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19360901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19360901"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Junli Liu, Dorina Ibi, Koji Taniguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2016.10.015"}], "href": "https://doi.org/10.1016/j.cell.2016.10.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27814504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27814504"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Datian Chen, Huiyu Wang "}, {"type": "b", "children": [{"type": "t", "text": "The clinical and immune features of CD14 in colorectal cancer identified via large-scale analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106966"}], "href": "https://doi.org/10.1016/j.intimp.2020.106966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33182067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33182067"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Karine Tremblay, Denise Daley, Annie Chamberland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2008.05.049"}], "href": "https://doi.org/10.1016/j.jaci.2008.05.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18774388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18774388"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "C Sackesen, E Birben, O U Soyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1398-9995.2010.02428.x"}], "href": "https://doi.org/10.1111/j.1398-9995.2010.02428.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20608916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20608916"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "H D Shin, K S Park, B L Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabet Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1464-5491.2005.01732.x"}], "href": "https://doi.org/10.1111/j.1464-5491.2005.01732.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16409569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16409569"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Karina Furlani Zoccal, Claudia da Silva Bitencourt, Francisco Wanderley Garcia Paula-Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0088174"}], "href": "https://doi.org/10.1371/journal.pone.0088174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24516606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24516606"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Donghee Kim, Jae Young Kim "}, {"type": "b", "children": [{"type": "t", "text": "Anti-CD14 antibody reduces LPS responsiveness via TLR4 internalization in human monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2013.09.009"}], "href": "https://doi.org/10.1016/j.molimm.2013.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24172224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24172224"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kok-Hooi Yew, Cory Carpenter, R Scott Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0044500"}], "href": "https://doi.org/10.1371/journal.pone.0044500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22970235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22970235"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Matteo Piazza, Liping Yu, Athmane Teghanemt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of a specific interaction between new synthetic antisepsis agents and CD14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi901601b"}], "href": "https://doi.org/10.1021/bi901601b"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19928913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19928913"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hui-Hua Li, Quan Li, Pengyuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2012-0127OC"}], "href": "https://doi.org/10.1165/rcmb.2012-0127OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22700866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22700866"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Miranda S Oakley, Victoria Majam, Babita Mahajan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0006793"}], "href": "https://doi.org/10.1371/journal.pone.0006793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19710907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19710907"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Leanne Thomas, Anne Bielemeier, Peter A Lambert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0070691"}], "href": "https://doi.org/10.1371/journal.pone.0070691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23936239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23936239"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Thiago Aparecido da Silva, André L V Zorzetto-Fernandes, Nerry T Cecílio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-07397-0"}], "href": "https://doi.org/10.1038/s41598-017-07397-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28765651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28765651"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Natalia Castaño-Rodríguez, Nadeem O Kaakoush, Khean-Lee Goh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060327"}], "href": "https://doi.org/10.1371/journal.pone.0060327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23565226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23565226"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Magdalena Druszczynska, Marcin Wlodarczyk, Grzegorz Kielnierowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0190106"}], "href": "https://doi.org/10.1371/journal.pone.0190106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29281719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29281719"}]}]}]}
|
Proteins | CD14_HUMAN |
NCBI Gene ID | 929 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
CD14 has 11,492 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 105 datasets.
Click the + buttons to view associations for CD14 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of CD14 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of CD14 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of CD14 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
Biocarta Pathways | pathways involving CD14 protein from the Biocarta Pathways dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of CD14 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of CD14 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of CD14 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with CD14 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with CD14 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD14 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of CD14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CD14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CD14 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing CD14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with CD14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of CD14 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with CD14 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with CD14 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with CD14 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by CD14 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with CD14 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with CD14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CD14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with CD14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with CD14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at CD14 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CD14 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of CD14 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing CD14 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with CD14 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with CD14 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with CD14 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing CD14 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of CD14 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding CD14 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving CD14 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving CD14 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing CD14 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing CD14 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by CD14 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by CD14 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CD14 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CD14 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of CD14 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of CD14 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of CD14 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
HuBMAP ASCT+B Annotations | cell types associated with CD14 gene from the HuBMAP ASCT+B dataset. | |
HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with CD14 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with CD14 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with CD14 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for CD14 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of CD14 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving CD14 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of CD14 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of CD14 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with CD14 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of CD14 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of CD14 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of CD14 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CD14 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing CD14 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain CD14 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by CD14 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting CD14 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of CD14 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by CD14 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for CD14 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of CD14 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
PANTHER Pathways | pathways involving CD14 protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for CD14 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of CD14 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of CD14 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving CD14 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving CD14 protein from the Wikipathways PFOCR 2024 dataset. | |
PID Pathways | pathways involving CD14 protein from the PID Pathways dataset. | |
Reactome Pathways 2014 | pathways involving CD14 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving CD14 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of CD14 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of CD14 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at CD14 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CD14 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CD14 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with CD14 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of CD14 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of CD14 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of CD14 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of CD14 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with CD14 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
WikiPathways Pathways 2014 | pathways involving CD14 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving CD14 protein from the WikiPathways Pathways 2024 dataset. | |