{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA CD27‐AS1 has emerged as an oncogenic regulator in several cancer types through distinct molecular mechanisms. In acute myeloid leukemia, CD27‐AS1 is markedly overexpressed and its high levels correlate with poor overall survival. Functional studies revealed that CD27‐AS1 acts as a competing endogenous RNA by sponging miR‐224‐5p, thereby enhancing PBX3 expression and activating downstream MAPK signaling, which promotes cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In melanoma, a specific nuclear‐localized isoform, CD27‐AS1‑208, facilitates tumor progression by directly interacting with STAT3; this interaction leads to increased melanoma cell proliferation, invasion, and migration via a STAT3‐dependent mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, CD27‐AS1 has been identified as a component of multi‐RNA prognostic signatures in cervical cancer and colon adenocarcinoma, where its differential expression is associated with disease recurrence and reduced disease‐free survival, underlining its potential as a valuable prognostic biomarker"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, CD27‐AS1 is involved in fusion gene events, as evidenced by its participation in a VAMP1–CD27‐AS1 conjoined transcript identified in non‐Hodgkin B‐cell lymphoma, suggesting that aberrant splicing or fusion events may further contribute to oncogenic processes in specific contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanling Tao, Jingjing Zhang, Lulu Chen, et al. 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