{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDH23-AS1 is a long non‐coding RNA transcribed in antisense orientation from the CDH23 locus that has been implicated in the regulation of cellular redox balance and transcriptional control. Our previous work demonstrated that Nrf1, a key transcription factor involved in oxidative stress responses and mitochondrial homeostasis, is influenced by non‐coding RNA-mediated regulatory mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, CDH23-AS1 appears to function as a modulator of Nrf1 signaling, thereby fine-tuning the transcription of genes critical for maintaining cellular homeostasis under stress conditions. The emerging evidence suggests that CDH23-AS1 could impact diverse biological processes including the oxidative stress response, mitochondrial function, and cellular metabolism, which may, in turn, contribute to various pathophysiological states. Further investigation into the mechanistic interplay between CDH23-AS1 and Nrf1 is likely to reveal new insights into its potential as both a biomarker and a therapeutic target in diseases characterized by dysregulated redox and metabolic signaling.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiayu Chen, Meng Wang, Yuancai Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Catenin-Dependent and Wnt/"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-Catenin-Independent Signaling Networks in the Human Liver Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/5138539"}], "href": "https://doi.org/10.1155/2020/5138539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32273945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32273945"}]}]}]}