CDH5 Gene

HGNC Family	CD molecules (CD), Cadherins
Name	cadherin 5, type 2 (vascular endothelium)
Description	This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDH5, which encodes vascular endothelial (VE)‐cadherin, is a transmembrane adhesion molecule expressed exclusively by endothelial cells that plays a central role in establishing and maintaining the integrity of adherens junctions. Through its extracellular domain, VE‐cadherin mediates homophilic cell–cell adhesion, thereby controlling paracellular permeability and serving as an important mechanosensor. For example, VE‐cadherin regulates the organization of tight junction proteins such as claudin‐5 by coordinating signaling events that limit vascular leak."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its expression and subcellular distribution are dynamically modulated by several upstream signals. In conditions of hypoxia or altered oxygen sensing, VE‐cadherin becomes one of the targets of HIF‐dependent pathways that help to restore vessel structure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the context of tumor progression, VEGF signaling disrupts the endothelial barrier by inducing the phosphorylation and subsequent internalization of VE‐cadherin, an event that facilitates tumor cell extravasation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " VE‐cadherin also functions as a key platform for mechanotransduction; its association with junctional proteins such as ZO‑1 and vinculin modulates the balance of cytoskeletal tension necessary for cell migration, angiogenesis, and the maintenance of the barrier function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, intracellular signaling pathways activated by cAMP—via the Epac–Rap1 axis—further enhance VE‐cadherin–dependent adhesion to stabilize endothelial junctions and reduce permeability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Under physiological flow conditions, shear stress–induced Src activation leads to specific phosphorylation of VE‐cadherin in veins, a modification that potentially primes the junctions for dynamic remodeling in response to inflammatory mediators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Furthermore, endothelial cells are protected from VEGF‐induced junctional disruption by Angiopoietin‑1 signaling, which prevents the redistribution and internalization of VE‐cadherin and helps to preserve barrier integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these studies collectively highlight that CDH5/VE‐cadherin is not only essential for the formation of a stable endothelial barrier but also is intricately regulated by multiple signaling pathways and mechanical forces. Its capacity to interact with a variety of cytoplasmic partners underlies its critical role in angiogenesis, inflammation‐induced permeability changes, and even tumor cell dissemination (1,2,3,4,5,6,7).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrea Taddei, Costanza Giampietro, Annarita Conti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1752"}], "href": "https://doi.org/10.1038/ncb1752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18604199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18604199"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Massimiliano Mazzone, Daniela Dettori, Rodrigo Leite de Oliveira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.01.020"}], "href": "https://doi.org/10.1016/j.cell.2009.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19217150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19217150"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sara Weis, Jianhua Cui, Leo Barnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200408130"}], "href": "https://doi.org/10.1083/jcb.200408130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15504909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15504909"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olga Tornavaca, Minghao Chia, Neil Dufton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201404140"}], "href": "https://doi.org/10.1083/jcb.201404140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25753039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25753039"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shigetomo Fukuhara, Atsuko Sakurai, Hideto Sano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.1.136-146.2005"}], "href": "https://doi.org/10.1128/MCB.25.1.136-146.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15601837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15601837"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fabrizio Orsenigo, Costanza Giampietro, Aldo Ferrari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2199"}], "href": "https://doi.org/10.1038/ncomms2199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23169049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23169049"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julie Gavard, Vyomesh Patel, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2007.10.019"}], "href": "https://doi.org/10.1016/j.devcel.2007.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18194650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18194650"}]}]}]}
Synonyms	CD144, 7B4
Proteins	CADH5_HUMAN
NCBI Gene ID	1003
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDH5 has 9,010 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for CDH5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDH5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CDH5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDH5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDH5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDH5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDH5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDH5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CDH5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDH5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDH5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDH5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CDH5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CDH5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDH5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDH5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDH5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDH5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CDH5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDH5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CDH5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDH5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CDH5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDH5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDH5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CDH5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CDH5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CDH5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CDH5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDH5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDH5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CDH5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CDH5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CDH5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDH5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDH5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDH5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CDH5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CDH5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CDH5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CDH5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CDH5 from the GeneSigDB Published Gene Signatures dataset.