CDK10 Gene

HGNC Family	Cyclin-dependent kinases (CDK)
Name	cyclin-dependent kinase 10
Description	The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cyclin‐dependent kinase 10 (CDK10) is a CDC2‐related kinase that has emerged as a key regulator of diverse cellular processes. Binding to its recently identified activating partner, cyclin M, CDK10 forms an active kinase complex that phosphorylates substrates such as ETS2 and PKN2. Phosphorylation of ETS2 promotes its proteasome‐dependent degradation, thereby modulating MAPK signaling and influencing the sensitivity of breast cancer cells to endocrine therapies such as tamoxifen."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In several tumors—including breast, biliary tract, hepatocellular, nasopharyngeal carcinomas, and glioma—reduced CDK10 expression correlates with enhanced proliferation, migratory behavior, metastatic potential, and resistance to chemotherapeutic agents, supporting a tumor‐suppressive role for CDK10."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": " In contrast, studies in colorectal cancer have revealed that high expression of CDK10 may be linked to suppression of apoptosis and enhanced tumor growth, underscoring a context‐dependent function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Beyond its roles in proliferation and survival, CDK10 is critical for the regulation of ciliogenesis. Deficiency in the CDK10/cyclin M complex alters actin network organization by affecting phosphorylation of PKN2, leading to enhanced assembly and elongation of primary cilia—a phenotype observed in patients with STAR or Al Kaissi syndromes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, CDK10 participates in diverse signaling networks, such as those integrating transcription factor activity (e.g. ETS2) in both wound healing and T-cell functions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and remains the only member of the CDK family for which small-molecule inhibitors are still being developed, highlighting its emerging promise as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vincent J Guen, Carly Gamble, Marc Flajolet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1306814110"}], "href": "https://doi.org/10.1073/pnas.1306814110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24218572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24218572"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P Khanal, H J Yun, S C Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.548"}], "href": "https://doi.org/10.1038/onc.2011.548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22158035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22158035"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maike Zimmermann, Aruni P S Arachchige-Don, Michaela S Donaldson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2016.1243189"}], "href": "https://doi.org/10.1080/15384101.2016.1243189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27753529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27753529"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jian-Hua Yu, Xiang-Yu Zhong, Wei-Guang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2011.1617"}], "href": "https://doi.org/10.3892/or.2011.1617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22209942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22209942"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiang-yu Zhong, Xiao-xue Xu, Jian-hua Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and biological significance of Cdk10 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.01.022"}], "href": "https://doi.org/10.1016/j.gene.2012.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22326270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22326270"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yanjie You, Haijun Li, Xin Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased CDK10 expression correlates with lymph node metastasis and predicts poor outcome in breast cancer patients - a short report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-015-0246-4"}], "href": "https://doi.org/10.1007/s13402-015-0246-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26392360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26392360"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanjie You, Wenjun Yang, Zhizhong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter hypermethylation contributes to the frequent suppression of the CDK10 gene in human nasopharyngeal carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-013-0137-5"}], "href": "https://doi.org/10.1007/s13402-013-0137-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23740091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23740091"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hui Li, Yanjie You, Jianfeng Liu "}, {"type": "b", "children": [{"type": "t", "text": "Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9059"}], "href": "https://doi.org/10.3892/mmr.2018.9059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29845196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29845196"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Louis-Bastien Weiswald, Mohammad R Hasan, John C T Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-16-0666"}], "href": "https://doi.org/10.1158/1535-7163.MCT-16-0666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28663269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28663269"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Vincent J Guen, Carly Gamble, Dahlia E Perez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2016.1147632"}], "href": "https://doi.org/10.1080/15384101.2016.1147632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27104747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27104747"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Thomas Robert, Anne-Catherine Dock-Bregeon, Pierre Colas "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.1782"}], "href": "https://doi.org/10.1002/mgg3.1782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34369103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34369103"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Panagiota Davoulou, Ioanna Aggeletopoulou, Ioannis Panagoulias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor Ets-2 regulates the expression of key lymphotropic factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-020-05865-x"}], "href": "https://doi.org/10.1007/s11033-020-05865-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33006713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33006713"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Meraj Zehra, Shamim Mushtaq, Syed Ghulam Musharraf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-48092-6"}], "href": "https://doi.org/10.1038/s41598-019-48092-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31413335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31413335"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Thomas Robert, Jared L Johnson, Roxane Guichaoua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of a CDK10/CycM "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Kinase Screening Assay and Identification of First Small-Molecule Inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fchem.2020.00147"}], "href": "https://doi.org/10.3389/fchem.2020.00147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32175313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32175313"}]}]}]}
Synonyms	ALSAS, PISSLRE
Proteins	CDK10_HUMAN
NCBI Gene ID	8558
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDK10 has 5,636 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for CDK10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDK10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CDK10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDK10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDK10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDK10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDK10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDK10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CDK10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CDK10 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CDK10 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDK10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDK10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CDK10 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDK10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDK10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CDK10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDK10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDK10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CDK10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CDK10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CDK10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CDK10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CDK10 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CDK10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CDK10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDK10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDK10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CDK10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CDK10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDK10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDK10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CDK10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.