{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDKN1A‐AS1 is a natural antisense long noncoding RNA that functions predominantly as an epigenetic regulator of gene expression. Transcribed from the strand opposite its sense partner, the CDKN1A gene, CDKN1A‐AS1 acts in cis by recruiting and bridging epigenetic effectors and regulatory complexes to its specific genomic locus, thereby modulating chromatin remodeling. This targeted mechanism facilitates precise alterations in chromatin state and consequent transcriptional control, processes that are fundamental to proper cellular development and are implicated in disease states (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marco Magistri, Mohammad Ali Faghihi, Georges St Laurent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tig.2012.03.013"}], "href": "https://doi.org/10.1016/j.tig.2012.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22541732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22541732"}]}]}]}