{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CEBPA‐AS1 is a long non‐coding RNA that exhibits diverse, context‐dependent regulatory functions in cancer and ischemic injury. In oral squamous cell carcinoma, for example, CEBPA‐AS1 is upregulated and acts as an oncogene by promoting cell proliferation, migration, and invasion while suppressing apoptosis through regulation of CEBPA and the CEBPA/Bcl2 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Elevated CEBPA‐AS1 levels have similarly been observed in liver cancer, where its overexpression is associated with increased tumor size, invasion, and an unfavorable prognosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and in lung adenocarcinoma as a component of a four‐lncRNA prognostic signature."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Diagnostic potential of CEBPA‐AS1 is underscored by its elevated expression in gastric cancer tissues and plasma, including its enrichment in circulating exosomes that enhance malignant behavior, which supports its use in noninvasive early detection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " In contrast, in osteosarcoma CEBPA‐AS1 is downregulated; its overexpression leads to upregulation of NCOR2 via miR‐10b‐5p sponging, thereby inhibiting cell proliferation and migration while dampening Notch signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In models of cerebral ischemia/reperfusion injury, heightened CEBPA‐AS1 expression contributes to neuronal apoptosis through its function as a competing endogenous RNA. It functions by sponging specific microRNAs (miR‐455 and miR‐340‐5p) to modulate targets such as GPER1 and the APPL1/LKB1/AMPK pathway, thereby influencing cell survival and neuroprotection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Moreover, in early onset colorectal cancer, alterations in CEBPA‐AS1 have been linked to adverse prognosis, hinting at a broader role beyond solid tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these studies demonstrate that CEBPA‐AS1 can function either as an oncogene or as a tumor suppressor depending on the tissue context, while also contributing to the pathophysiology of ischemic injury. Its multifaceted roles in cell proliferation, apoptosis, invasion, and diagnostic biomarker potential highlight CEBPA‐AS1 as a promising target for future therapeutic and prognostic applications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Guo, Yuji Ma, Xuanhao Hu, et al. 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