{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CEBPB‐AS1 is an antisense long non‐coding RNA that modulates the expression of the transcription factor CEBPB through epigenetic mechanisms. In metastatic cutaneous malignant melanoma, silencing of CEBPB‐AS1 induces epigenetic changes in the CEBPB promoter, leading to elevated CEBPB mRNA and protein levels, reduced cellular proliferation, and increased sensitivity of BRAF‐inhibitor–resistant cells to drug‐induced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " More broadly, the regulatory functions of long non‐coding RNAs—including those like CEBPB‐AS1—encompass transcriptional and post‐transcriptional modulation via interactions with histone‐modifying complexes, DNA, transcription factors, and other regulatory proteins or RNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings highlight the importance of CEBPB‐AS1 in fine‐tuning gene expression relevant to therapeutic responses in melanoma and illustrate how lncRNAs serve as pivotal regulators in various biological processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Linda Vidarsdottir, Rita Valador Fernandes, Vasilios Zachariadis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000675"}], "href": "https://doi.org/10.1097/CMR.0000000000000675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32467529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32467529"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4010003"}], "href": "https://doi.org/10.3390/ncrna4010003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29657300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29657300"}]}]}]}