{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCAAT/enhancer binding protein gamma (CEBPG) is emerging as a multifunctional transcriptional regulator with roles in diverse biological contexts. In epithelial ovarian cancer, increased CEBPG expression—upregulated by circulating exosomal circRNAs—not only correlates with advanced disease features but also confers cisplatin resistance by promoting cell proliferation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In immune cells, CEBPG acts as a context‐dependent modulator; it forms heterodimers with C/EBPβ to markedly enhance lipopolysaccharide‐induced interleukin‐6 and interleukin‐8 promoter activity in B lymphoblasts"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while in T cells, its binding to the positive regulatory element‐I and cooperation with Fos facilitate transcription of the interleukin‐4 gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Supporting its role in B cell development, the Ig/EBP‐1 protein—closely related to CEBPG—selectively activates immunoglobulin heavy chain promoters in early B cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the lung, CEBPG directly up‐regulates the DNA repair gene ERCC5 and is intricately linked with the expression of key antioxidant genes in normal bronchial epithelial cells; disruptions in these regulatory interactions may contribute to increased susceptibility to bronchogenic carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In hepatic cells, during fasting conditions, CEBPG cooperates with ATF5 to stimulate the promoter activity of PGC‐1α, thereby facilitating the induction of gluconeogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in hematopoiesis, overexpression of Trim27 leads to up‐regulation of CEBPG among other regulators, supporting myeloid‐biased differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, aberrant CEBPG expression is part of a genetic signature that distinguishes individuals with a high propensity for heroin addiction, underscoring its potential as a biomarker in neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these studies highlight the pivotal and context‐dependent functions of CEBPG in transcriptional regulation, impacting processes as varied as oncogenesis, immune responses, DNA repair, metabolic adaptation, and stem cell differentiation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanwei Luo, Rong Gui "}, {"type": "b", "children": [{"type": "t", "text": "Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gynecol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3802/jgo.2020.31.e75"}], "href": "https://doi.org/10.3802/jgo.2020.31.e75"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32808501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32808501"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongwei Gao, Sara Parkin, Peter F Johnson, et al. 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