{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CECR9 is one of several putative genes identified within a 1.1‐Mb segment of human chromosome 22q that defines the critical region implicated in cat eye syndrome (CES)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This gene, along with CECR3, was discovered through comparative analysis of orthologous regions in the human and mouse genomes, despite the absence of expressed sequence tag (EST) evidence to support its transcription. Its identification via conserved genomic segments underscores the utility of comparative genomic methods in pinpointing candidate genes in dosage-sensitive regions. Although the function of CECR9 has not yet been characterized, its localization within the distal CES critical region—which harbors most of the candidate genes for CES—suggests that it could potentially contribute to the phenotype observed in this syndrome.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T K Footz, P Brinkman-Mills, G S Banting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.154901"}], "href": "https://doi.org/10.1101/gr.154901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11381032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11381032"}]}]}]}