| Name | centromere protein S |
| Description | This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Centromere protein‐S (CENP‑S) is a key component of the constitutive centromere‐associated network (CCAN) that helps assemble and stabilize the kinetochore—the macromolecular complex essential for linking centromeric chromatin to spindle microtubules during mitosis. In particular, the CENP‑S–containing subcomplex (together with its binding partner CENP‑X) is required for the proper formation of the kinetochore outer plate. Although cells lacking CENP‑S and CENP‑X can remain viable, their depletion causes abnormal mitotic behaviors including a significant reduction in the size of the outer plate and an increase in the intrakinetochore distance, which together indicate deficient kinetochore structural integrity. The localization of the CENP‑S complex at kinetochores depends on upstream components such as CENP‑T and CENP‑K, positioning it within an interdependent network that ensures robust kinetochore assembly and proper microtubule engagement for accurate chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Miho Amano, Aussie Suzuki, Tetsuya Hori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CENP-S complex is essential for the stable assembly of outer kinetochore structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200903100"}], "href": "https://doi.org/10.1083/jcb.200903100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19620631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19620631"}]}]}]}
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| NCBI Gene ID | 378708 |
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| Predicted Functions |
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| Expression in Tissues and Cell Lines |
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CENPS has 669 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.
Click the + buttons to view associations for CENPS from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Proteomics | Cell lines associated with CENPS protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CENPS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of CENPS gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of CENPS protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with CENPS gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CENPS gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CENPS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving CENPS gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by CENPS gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with CENPS gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving CENPS protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving CENPS protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of CENPS gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CENPS gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CENPS gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| WikiPathways Pathways 2024 | pathways involving CENPS protein from the WikiPathways Pathways 2024 dataset. | |
