{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Centrosomal protein CEP20 (often referred to as FOR20) is a highly conserved regulatory factor that plays multiple essential roles in organizing centrosomal function, microtubule dynamics, cilium assembly, and cell cycle progression. CEP20 localizes to centrosomes, where it associates with pericentriolar satellites and basal bodies. In this capacity it helps recruit key factors such as polo‐like kinase 1 (Plk1) during S phase, thereby promoting timely DNA replication and proper cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, CEP20 is critical for the assembly and stability of microtubule arrays; it modulates the transport and organization of centriolar satellite components to the centrosome, thus facilitating microtubule nucleation and maintaining the radial array of microtubules. Its function in ciliogenesis is equally pivotal—in diverse model systems ranging from zebrafish to unicellular organisms such as Paramecium and Trypanosoma, CEP20 participates in the early steps of ciliary vesicle recruitment, transition zone formation, and basal body docking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In addition, studies in mammalian embryogenesis have revealed that disruption of CEP20 function impairs angiogenesis and proper left–right patterning, underscoring its broader developmental importance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these observations establish CEP20 as a central hub for the coordination of centrosome-mediated processes—from ensuring robust microtubule organization and facilitating cell cycle progression to initiating and stabilizing primary cilium formation—and highlight its potential relevance in human developmental disorders and diseases linked to centrosomal dysfunction.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Minhong Shen, Yuqi Cai, Yuehong Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Centrosomal protein FOR20 knockout mice display embryonic lethality and left-right patterning defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.14071"}], "href": "https://doi.org/10.1002/1873-3468.14071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33686659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33686659"}]}]}]}