{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>CEP83-AS1 Functional Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into long noncoding RNAs (lncRNAs) across different disease models have identified CEP83-AS1 as a candidate regulator in both cardiovascular and bone disorders. In a study of dilated cardiomyopathy (DCM), genome‑wide profiling of circulating lncRNAs revealed that a number of these molecules—including CEP83‑AS1—were significantly dysregulated. Bioinformatics analyses in this context associated such lncRNAs with processes in system development, organ morphogenesis, and metabolic regulation, as well as with pathways involving gap junction communication, phagosome function, and cardiomyopathy signaling. These findings suggest that CEP83‑AS1 may contribute to cardiac pathology by modulating gene networks that are essential for maintaining proper heart structure and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a parallel investigation focused on osteoporosis, analysis of osteoblast primary cultures derived from patients pointed to an aberrant expression of several lncRNAs, reflecting a disruption in bone homeostasis likely linked to enhanced inflammatory signaling and excessive bone resorption. Within this regulatory milieu, CEP83‑AS1 is posited to influence inflammatory responses and osteoblast function, thereby offering a potential mechanistic connection between its misregulation and the progression of osteoporosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, the available evidence indicates that CEP83‑AS1, as a dysregulated lncRNA, may serve as a multifaceted regulatory element. Its involvement in key developmental and metabolic pathways in DCM, coupled with a possible role in modulating inflammation in osteoporosis, positions CEP83‑AS1 as an attractive target for further studies aimed at elucidating its precise molecular mechanisms and potential utility as a biomarker in these complex diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guangyong Huang, Jingwen Liu, Chuansheng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA sequencing discloses the genome‑wide profile of long noncoding RNAs in dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.9937"}], "href": "https://doi.org/10.3892/mmr.2019.9937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30720098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30720098"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Federica Centofanti, Massimo Santoro, Mario Marini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Aberrantly-Expressed Long Non-Coding RNAs in Osteoblastic Cells from Osteoporotic Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomedicines (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biomedicines8030065"}], "href": "https://doi.org/10.3390/biomedicines8030065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32204466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32204466"}]}]}]}