{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCerox1 is an unusually abundant cytoplasmic long noncoding RNA that plays a critical role in post‐transcriptional regulation of mitochondrial energy production. It modulates the abundance of electron transport chain complex I subunit transcripts by binding to microRNA-488-3p, thereby relieving miRNA-mediated repression. This interaction increases the levels of complex I proteins and enzymatic activity, reduces reactive oxygen species production, and confers protection against mitochondrial inhibitors like rotenone."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nFurthermore, the function of Cerox1 is conserved in placental mammals, as evidenced by the ability of both human and mouse orthologues to effectively modulate complex I activity across species. This conserved regulatory mechanism highlights Cerox1 and its interaction with microRNA-488-3p as promising targets for modulating mitochondrial oxidative phosphorylation and potentially for therapeutic intervention in diseases associated with mitochondrial dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tamara M Sirey, Kenny Roberts, Wilfried Haerty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.45051"}], "href": "https://doi.org/10.7554/eLife.45051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31045494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31045494"}]}]}]}