{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA CERS6‐AS1 is emerging as a multifaceted regulator in various human diseases, particularly in cancers and neurological disorders. In breast cancer, CERS6‐AS1 is overexpressed and promotes tumor progression by enhancing cell proliferation and reducing apoptosis. Mechanistically, it binds to the RNA‐binding protein IGF2BP3 to stabilize CERS6 mRNA, thereby facilitating malignant development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic cancer, CERS6‐AS1 acts as a competitive endogenous RNA (ceRNA). It functions as a molecular sponge for different microRNAs—including miR‐217‑5p, miR‐15a‑5p, miR‑6838‑5p, and miR‑195‑5p—to regulate the expression of key downstream oncogenic targets such as YWHAG/RAF1, HMGA1, and WIPI2, ultimately promoting cell growth, migration, invasion, and epithelial to mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, additional evidence indicates that CERS6‐AS1 may promote tumorigenesis by sponging miR‑125a‑5p to upregulate BAP1 expression, further contributing to cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in colorectal and gastric cancers, CERS6‐AS1 is upregulated and contributes to malignant behaviors by sequestering miR‑15b‑5p and miR‑567, respectively, thereby elevating the expression of SPTBN2 in colorectal cancer and enhancing proliferation, migration, and invasion in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in tumorigenesis, CERS6‐AS1 has also been implicated in non‐cancer conditions. In the context of right ventricular cardiomyopathy induced by tricuspid regurgitation, CERS6‐AS1 is integrated into a ceRNA network with miR‑497‑5p and OPN4, suggesting a potential contribution to cardiac pathophysiology through modulation of RNA interaction networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, network analyses in Alzheimer’s disease have identified CERS6‐AS1 as a potential biomarker within a larger lncRNA‐associated ceRNA framework, linking it to neurobiological processes such as neuron projection development and synaptic transmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings reveal that CERS6‐AS1 orchestrates disease progression by functioning as a ceRNA that modulates the stability or activity of critical mRNAs and signaling pathways across distinct biological systems. Its ability to sponge various microRNAs and interact with RNA‐binding proteins highlights its potential utility as a prognostic biomarker and therapeutic target in diverse clinical contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Bao, Jianjun Huang, Wei Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2675"}], "href": "https://doi.org/10.1002/cam4.2675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31701672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31701672"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Xu, Jie Wang, Zhiwei He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03921-3"}], "href": "https://doi.org/10.1038/s41419-021-03921-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34168120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34168120"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rongxi Shen, Xinbo Wang, Sizhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA CERS6-AS1 Accelerates the Proliferation and Migration of Pancreatic Cancer Cells by Sequestering MicroRNA-15a-5p and MicroRNA-6838-5p and Modulating HMGA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pancreas (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPA.0000000000001806"}], "href": "https://doi.org/10.1097/MPA.0000000000001806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33939677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33939677"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kan-Fei Gao, Yu-Fang Zhao, Wu-Jun Liao, et al. 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