| Name | ceramide transporter 1 |
| Description | This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Ceramide transfer protein 1 (CERT1) is a cytosolic lipid transfer protein that mediates the non‐vesicular transport of ceramide from the endoplasmic reticulum to the Golgi apparatus for conversion to sphingomyelin. CERT1 contains a pleckstrin homology (PH) domain that binds phosphatidylinositol 4‐monophosphate to target the Golgi, a steroidogenic acute regulatory protein–related lipid transfer (START) domain that selectively binds and transfers natural ceramide species, and an FFAT motif that interacts with ER‐resident VAP proteins—features that spatially confine its activity to ER–Golgi contact sites."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Structural analyses of its START domain have revealed the molecular determinants responsible for its stereo‐selective and acyl chain–length–restricted recognition of ceramide."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " CERT1 activity is further regulated by phosphorylation events. For instance, phosphorylation by protein kinase D at serine residues (e.g. S132 and S315) modulates its association with both phosphatidylinositol 4‐monophosphate and VAP proteins, thereby tuning ceramide transfer activity and ultimately influencing sphingomyelin synthesis and secretory transport."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " In addition, CERT1 plays a critical role in maintaining cellular sphingolipid homeostasis, as perturbations in its function affect not only the biosynthesis of sphingomyelin but also downstream processes such as viral morphogenesis and mitochondrial integrity, with deficiencies leading to aberrant ceramide accumulation and developmental defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kentaro Hanada, Keigo Kumagai, Satoshi Yasuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular machinery for non-vesicular trafficking of ceramide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02188"}], "href": "https://doi.org/10.1038/nature02188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14685229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14685229"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miyuki Kawano, Keigo Kumagai, Masahiro Nishijima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605032200"}], "href": "https://doi.org/10.1074/jbc.M605032200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16895911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16895911"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Keigo Kumagai, Satoshi Yasuda, Kazuo Okemoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CERT mediates intermembrane transfer of various molecular species of ceramides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409290200"}], "href": "https://doi.org/10.1074/jbc.M409290200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15596449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15596449"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Norio Kudo, Keigo Kumagai, Nario Tomishige, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0709191105"}], "href": "https://doi.org/10.1073/pnas.0709191105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18184806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18184806"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tim Fugmann, Angelika Hausser, Patrik Schöffler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200612017"}], "href": "https://doi.org/10.1083/jcb.200612017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17591919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17591919"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Balázs Tóth, András Balla, Hui Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604935200"}], "href": "https://doi.org/10.1074/jbc.M604935200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17003043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17003043"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Keigo Kumagai, Miyuki Kawano-Kawada, Kentaro Hanada "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.528380"}], "href": "https://doi.org/10.1074/jbc.M113.528380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24569996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24569996"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yutaka Amako, Gulam H Syed, Aleem Siddiqui "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.182097"}], "href": "https://doi.org/10.1074/jbc.M110.182097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21285358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21285358"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xin Wang, Raghavendra Pralhada Rao, Teresa Kosakowska-Cholody, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200807176"}], "href": "https://doi.org/10.1083/jcb.200807176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19139267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19139267"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Norio Kudo, Keigo Kumagai, Ryosuke Matsubara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2009.12.029"}], "href": "https://doi.org/10.1016/j.jmb.2009.12.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20036255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20036255"}]}]}]}
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| NCBI Gene ID | 10087 |
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| Expression in Tissues and Cell Lines |
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CERT1 has 3,012 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 44 datasets.
Click the + buttons to view associations for CERT1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CERT1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of CERT1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with CERT1 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with CERT1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CERT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with CERT1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing CERT1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing CERT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing CERT1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with CERT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by CERT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CERT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CERT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with CERT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving CERT1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving CERT1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing CERT1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing CERT1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by CERT1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by CERT1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CERT1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of CERT1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with CERT1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by CERT1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of CERT1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of CERT1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of CERT1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of CERT1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by CERT1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of CERT1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving CERT1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving CERT1 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving CERT1 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of CERT1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of CERT1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of CERT1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CERT1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CERT1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of CERT1 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of CERT1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CERT1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CERT1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with CERT1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving CERT1 protein from the WikiPathways Pathways 2024 dataset. | |
