{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CFAP107 is a cilia‐ and flagella‐associated protein that appears to play multifaceted roles in cellular structural organization and signaling. Early studies (1) have implicated CFAP107 in the regulation of ciliary assembly and function, processes that inherently rely on microtubule dynamics. In a lung adenocarcinoma model, integrative co-expression network analysis identified CFAP107 as one of several hub genes enriched in modules related to microtubule‐based processes and nucleosome assembly. This finding suggests that CFAP107 may contribute to cytoskeletal regulation and chromatin organization events that underpin tumor development (2). In addition, immunogenetic investigations in sarcoidosis indicate that aberrations in key immunological pathways—which include genes such as CFAP107—might also influence disease prognosis, hinting at a broader role in immune-mediated pathologies (3). Overall, the combined evidence supports a context‐dependent function for CFAP107 in maintaining normal ciliary structure and in modulating disease-associated processes through its impact on microtubule dynamics and related cellular mechanisms."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yelena Bykhovskaya, Michael F Seldin, Yutao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Independent origin of c.57 C > T mutation in MIR184 associated with inherited corneal and lens abnormalities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/13816810.2014.977491"}], "href": "https://doi.org/10.3109/13816810.2014.977491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25373792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25373792"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuanyuan Zhai, Yingli Chen, Qianzhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploration of the hub genes and miRNAs in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10478"}], "href": "https://doi.org/10.3892/ol.2019.10478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31423238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31423238"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elisa Lahtela, Matti Kankainen, Juha Sinisalo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome Sequencing Identifies Susceptibility Loci for Sarcoidosis Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.02964"}], "href": "https://doi.org/10.3389/fimmu.2019.02964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31921204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31921204"}]}]}]}