{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A review of the provided abstracts reveals that none of them assess or mention the gene CFAP141. The first abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "describes a novel large deletion in the TPM3 gene associated with nemaline myopathy, emphasizing the impact of copy number variation in a disease typically linked to point mutations. The second abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "investigates blood-based gene expression biomarkers in chronic neuropathic pain, with a focus on the upregulation of TIMP1 as a potential diagnostic marker. The third abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "examines changes in DNA methylation in peripheral blood following Roux-en-Y gastric bypass surgery, highlighting alterations in pathways related to inflammation, angiogenesis, and apoptosis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n As none of these studies provide data on the function or clinical relevance of CFAP141, no conclusions regarding its role can be drawn from these abstracts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "K Kiiski, V-L Lehtokari, A Y Manzur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Large Deletion Affecting TPM3, Causing Severe Nemaline Myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuromuscul Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JND-150107"}], "href": "https://doi.org/10.3233/JND-150107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27858751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27858751"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David A Buckley, Elaine M Jennings, Nikita N Burke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-017-0492-8"}], "href": "https://doi.org/10.1007/s12035-017-0492-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28361271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28361271"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C F Nicoletti, M A S Pinhel, A Diaz-Lagares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-019-0522-7"}], "href": "https://doi.org/10.1186/s12920-019-0522-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31133015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31133015"}]}]}]}